Greentech's new Holobiosys was developed using a metaproteomic study method that examines all proteins in microbial communities to take into account the specific function of each cellular protein. In applications, the ingredient restores skin hydration, imparts smoothing effects and invigorates the skin holobiont.
How Holobiosys was Developed
The study of the holobiont, a consortium of the body and all microorganisms present on/in it, provides a comprehensive view of the interactions between the skin and its microbial ecosystem.
This systemic method reportedly allowed Greentech to develop a technology that treats the skin as a whole to address the slowdown of skin barrier and antioxidant functions associated with aging and loss of hydration.
How Holobiosys Works
Holobiosys repairs conditions of dry and dehydrated skin via
- a boost of hyaluronic acid (HA) in the epidermis and dermis via stimulation of the HA receptor CD44;
- and skin lipid synthesis in keratinocytes for a more cohesive epidermis able to lock in skin moisture.
The technology also stimulates dermal-epidermal junction markers expression for a better diffusion of water bound to HA within the skin.
In addition, antioxidant cell responses are upregulated after treatment with Holobiosys both in keratinocytes and fibroblasts for protection against HA degradation by free radicals.
In clinical tests with volunteers, the ingredient purportedly increased skin hydration index after 28 days of application at 1% vs placebo and smoothed wrinkles. It also protected hydrolipidic film and had a lipid-replenishing effect on a sub-panel presenting dehydrated and sebum-deficient skin.
Holobiosys is derived via an "upcycled" fermentation process that applies a cold-tolerant bacteria from the French aerobiota to wild yellow gentian root extract.