Skin aging, in particular when induced by chronic ultraviolet (UV) exposure, leads to degenerative changes in the skin. Ultraviolet light also increases metalloproteinase activity. This leads to a breakdown of collagen at a higher rate than with just regular aging. The consequences are manifold, such as increased skin fragility, leathery skin appearance and formation of superficial fine wrinkles. If not taken care of, these fine lines become visible to others.
Consequently, anti-wrinkle products are the first choice if consumers want to reduce the appearance of wrinkles or to stave off the first signs of aging.
SYN-Coll, a small molecular synthetic peptide (see Figure 1), has been designed to prevent the formation of wrinkles and to reduce their appearance. Peptides are made up of amino acids, which are the major components of all living cells, including skin cells. Peptides are very useful ingredients in cosmetic formulas; they help revitalize the skin and counter the effects of UV-induced premature aging.
Collagen represents the main component of the Extracellular Matrix (ECM) of the dermal connective tissue. Thrombospondin I (TSP) is a multifunctional protein that activates the latent but biologically inactive form of Tissue Growth Factor (TGF-β), which is known as the key element in the synthesis of collagen. Similar to TSP, our peptide molecule binds to latent TGF-β and initiates its activation to fully functional TGF-β (demonstration in vitro), as shown in Figure 2.
This innovative mechanism made our peptide a unique and specific TGF-β booster. It comprises the increase of the collagen and simultaneously protects collagen from degradation through MMP inhibition (demonstration in vitro). Comprehensive clinical tests show strong results on the appearance of all types of age-related wrinkles (see Figure 3) and have confirmed its safety for cosmetic use.
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