Revolutionizing Retinol, Vitamin A Release Via Microcapsules


When you read the ‘active ingredients’ on a product’s label, you may be surprised to learn that much of their ‘activity’ is lost by the time you actually use the product. Through oxidation, temperature, light exposure, expiration dates, or other factors, ingredients such as Retinol and Vitamin A lose effectiveness, can change a product’s look, and may not act as you expected when purchased.

Tagra Biotechnologies’ innovative microencapsulation technology uses an impermeable, naturally elastic, cellulose-based polymer shell keeping the active ingredient safe until use. These CelluCaps™️ increase formulation capacity and enhance active ingredient performance, stability, and release.

How does it work?

The microcapsules that contain the ingredient look like powder to the naked eye and only release the active element when you rub the infused formula on your skin. This means that the ingredient’s effects are only activated when in use, preserving their potency. Additionally, the capsules create a more versatile formulation process. By separating active ingredients, like oils and pigments, and transforming them into powder-looking capsules, manufacturers can easily combine elements that otherwise would not interact and come up with new and innovative formulas.

What Does This Look Like In Practice?

Skincare professionals consistently promote creams and lotions touting the presence of active ingredients, even though they lose efficacy and can discolor formulas. Retinol and Vitamin A, two compounds associated with anti-aging, restorative skin properties, are specifically troublesome when it comes to preserving their benefits. Retinol, known for its ability to stimulate collagen production and accelerate cell reproduction, is incredibly sensitive to oxidation, sunlight, and heavy metals. Likewise, Vitamin A, a natural anti-oxidant used in acne formulas to ward off inflammation and promote better skin health, is incredibly susceptible to losing its strength.


As a leader in microencapsulation, Tagra applied its solution to Retinol (CelluCap™️ R) and Vitamin A (CelluCap™️ A) and created longer-lasting, more successful skincare formulas. The capsules stop Retinol and Vitamin A from diffusing within the formula and discoloring it as a result of unintended ingredient interactions, all the while keeping both ingredients potent until skin contact. Discover how CelluCap™️ R takes your formulations to the next level in this video:

In a third-party clinical study, 20 women applied a CelluCap™️ R-infused formula to their skin for 4 weeks, twice a day. At the conclusion of the study, the women saw an average of 11.2% improvement in the appearance of wrinkles and a 55.3% enhancement in skin firmness with zero skin irritation. When compared to formulas with free Retinol infused in it, the findings do not even compare. All women agreed that their skin looked healthier and firmer, and they would even recommend the product to a friend.


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Microencapsulation technology is transforming cosmetic formula creation and benefits by opening up the possibility for new and innovative formula mixtures and skincare solutions. Beyond Retinol and Vitamin A, Tagra’s R&D lab is developing a sophisticated line of encapsulated anti-aging, anti-acne, brightening, pigment, moisturizing, and sun care ingredients. And while the technology continues to advance, the results make it clear: microencapsulation technology is the future of the cosmetic industry. 


To learn more about Tagra’s groundbr­eaking retinol and vitamin A CelluCaps™️, share your contact information to download our study data today! 


For more information, please email us: [email protected], call us: +972 (0)98656454, or visit our website www.tagra.com.


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