When the Dust Settles: Keratinocyte Differentiation is the Anti-pollution Solution

Jun 29th, 2017
Anne-Françoise Clay, Valère Busuttil, Isabelle Imbert, Christophe Capallere, Laurine Bergeron, Catherine Serre, Christelle Plaza, Gilles Oberto, Karine Cucumel, Jean-Marie Botto and Nouha Domloge, Ashland Specialty Ingredients, Vincience, Nice, France
CT170708_Clay_pic1_850x850

Daily, the human body encounters many stresses to which the skin acts as the first external barrier. Environmental pollution is one stressor and is present in many forms, including volatile organic compounds, cigarette smoke, ozone as well as particulate matter (PM). This persistent presence of urban pollution has become increasingly problematic in large cities worldwide. It affects not only the quality and beauty of skin, but also barrier function; these deleterious effects have been studied and demonstrated.1

TL Pan et al, The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption, J Dermatol Sci 78(1) 51-60 (2015)

M Ketz et al, Suppression of progenitor differentiation requires the long noncoding RNA ANCR, Genes Dev 26(4) 338-43 (2012)

M Ketz, et al, Control of somatic tissue differentiation by the long non-coding RNA TINCR, Nature 493(7431) 231-5 (2013)

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