Testing

Recent in Testing (page 26 of 32)

A Dermatological View—Squamometry: An Early Predictor of Changes in the Skin Barrier

Squamometry is useful in identifying the low or subclinical irritation potential of substances even before any change in the TEWL can be measured.

Testing Tactics: In Vitro Approaches to Antiaging Testing

Using proper methods, it is possible to screen materials for potential antiaging effects; in turn, these materials can be incorporated into cosmetic or personal care products. To properly screen antiaging materials, all that is required is a basic understanding of the aging process.

Modeling UVB-induced Formation of Photoproducts in Human Keratinocytes

The authors describe a model to visualize the appearance of cyclobutane-pyrimidine dimers in the nuclei of normal human keratinocytes after UV irradiation. These dimers are one of the principal agents in DNA damage. The model can be used to assess the effect of a cosmetic ingredient on the formation of direct UV-induced lesions to DNA.

NICEATM Requests Info on the Murine Local Lymph Node Assay

The US National Toxicology Program (NTP), Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) has requested comments, nominations of scientific experts and submission of data on the murine local lymph node assay.

EU and US Discuss Animal Testing

A framework has been established between the European Union (EU) and the United States that is expected to produce greater cooperation in the cosmetic and personal care industry.

Colipa Approves Animal Testing Alternatives

Colipa announced yesterday that The European Centre for the Validation of Alternative Methods (EVCAM) scientific committee now endorses new safety test methods that eliminate animal testing.

Texture Analysis to Select Packaging and Formulate Hair Care Products

Texture analysis provides quantitative information about a material’s response when deformed by a controlled force. Examples illustrate the use of a texture analyzer to evaluate shampoo extrusion, hair spray film toughness, hair spray tackiness, styling wax hardness and aerosol canister deployment.

Measuring Reactive Oxygen Species in Skin with Fluorescence Microscopy

Several signs of skin aging have been attributed to the presence of free radicals. This paper discusses the application of two-photon fluorescence microscopy to determine the effects of sample formulations on the number of reactive oxygen species (ROS) formed in skin models.

Testing Tactics--In Vitro Sensitization Models: Current Progress

Several interesting and promising approaches to in vitro skin sensitization testing are in development. Perhaps it will not be long before they are deemed valid and reliable alternatives to animal testing.

Enhancing, Measuring Skin Penetration

Skin penetration is of great interest to personal care formulators for many reasons. Following are a few recent findings.

Tech Edge--Optical Tools to Examine the Structure of Cosmetics Products

To monitor or anticipate what can happen in the creation of a cosmetic product when components are combined and as time passes is no trivial task especially when compounded with the psychophysical needs for the product to fit a specific concept and to spread, feel, pour and appear elegant.

A Dermatological View: Antioxidant Inhibits UV Erythema In Vivo in Humans

Described here was an in vivo model to determine antioxidative capacity of a topical skin care emulsion versus the emulsion’s vehicle on human skin that was exposed to UVR. Results suggest the test emulsion and its vehicle control inhibited the induction of erythema and reduced inflammation caused by the UV exposure.

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Practical Modern Hair Science

Practical Modern Hair Science

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Apply Topically: A Guide to Formulating

Apply Topically: A Guide to Formulating

Finally! This book offers practical approach to the formulation chemist’s day-to-day endeavors by: addressing the innumerable challenges facing the chemist both in design and at bench, such as formulating with/for specific properties; offering valuable “tips” to troubleshooting issues regarding ingredient selection and interaction, regulatory concerns that must be addressed early in development, and the extrapolation of preservative systems; exploring the advantages and limitations of raw materials; addressing scale-up and pilot production process and concerns; and much more.Order your copy today.