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May 02, 2011 | 01:22 PM CDT
By: Eric. S. Abrutyn, TPC2 Advisors Ltd., Inc.
The fingernail or nail plate is a complex matrix comprising closely packed keratinized epithelial cells or onychocytes—cross-linked cysteine bond matrix proteins containing inorganic elements such as sulfur as well as calcium, sodium, iron, aluminum, copper, etc.
Apr 06, 2011 | 10:49 AM CDT
A Review of Anti-irritants, Part II: Moisturizer, Anti-irritant Efficacy and Overall Interpretation*
By: Howard I. Maibach, MD, and Hongbo Zhai, MD, Un…
his column is the second of a two-part series about anti-irritants. Part I appeared in the March 2011 issue and covered anti-irritants, irritant reaction and barrier cream efficacy. The present column summarizes the efficacy of moisturizers and anti-irritant substances and provides an overall interpretation.
Apr 06, 2011 | 10:43 AM CDT
By: Stacy A. Mundschau, Scott W. Wenzel and Barbar…
When developing moisturizers intended for application via nonwoven substrates, formulators must consider the hydrophobic oils, the affinity of those oils to the substrate, the add-on to the substrate and the stability of the compositions on the substrate. With these considerations, moisturizing formulations were developed and coated onto laminated substrates whose moisturization efficacies were evaluated as described here.
Apr 06, 2011 | 10:40 AM CDT
By: Thanaporn Amnuaikit, Wiwat Pichayakorn and Pra…
This article compares the ability of mixed emulsifier nanoemulsions and polysorbate 60 emulsions to deliver coenzyme Q10 and tocopheryl acetate into the skin. In vitro skin penetration data shows that in newborn pig skin, nanoemulsions can deliver higher amounts of both actives than emulsions.
Apr 05, 2011 | 05:25 PM CDT
By: Robert J. Coots, PhD, Colonial Chemical Inc.
The use of sulfonated alkyl polyglucosides (SAPG) to replace lauryl sulfates and lauryl ether sulfates in sulfate-free formulations has previously been discussed. These primary surfactants were created with environmental and human safety in mind. The current paper describes more recent work with this material, specifically focusing on the lauryl version of SAPG.
Apr 05, 2011 | 05:22 PM CDT
By: Eric S. Abrutyn, TPC2 Advisors Ltd., Inc.
Frizz control hair care has been around for almost 20 years. Frizzy hair is a major issue for women with curly hair that has especially been chemically or mechanically treated.
Mar 02, 2011 | 03:49 PM CST
By: Alain Thibodeau, PhD, Innovacos Corp.
Aging triggers the modification of gene expression levels, negatively affecting skin’s ultrastructural integrity and resulting in dry, saggy skin and the appearance of wrinkles. However, an extract of Saccharina longicruris has been found to restore the expression levels of specific genes in senescent fibroblasts, in turn improving barrier function and hydration, increasing elasticity and reducing wrinkles, which are described in this article.
Mar 02, 2011 | 03:42 PM CST
By: Laurent Rios, PhD; Cédric Delattre, PhD; Paola…
Effective slimming actives should reduce lipogenesis, increase lipolysis, promote fatty acid release and improve skin firmness. Here, the authors describe the development of such an active based on polyglucuronic acid. Further, this material is shown to act on a new biological pathway involving the fasting-induced adipose factor (FIAF) adipokine.
Mar 02, 2011 | 03:36 PM CST
By: N. Dayan, PhD, Lipo Chemicals Inc.; A. Ballant…
High energy visible (HEV) light recently has been suspected of causing as much damage as UVA and UVB combined. Thus, the present paper describes a fractionated melanin tailored to absorb light in the visibile 400–500 nm range. In addition, because the material exhibits color, the authors focus on formulation techniques to incorporate it into semi-solid formulations.
Feb 03, 2011 | 03:21 PM CST
By: Luigi Rigano and Chiara Andolfatto, Rigano Con…
The versatility of hyaluronic acid is connected to not only its size, but also to inherent opportunities within the molecule for multiple bonds and for the differentiated release of bound functional molecules. Here, ester bonds are used to introduce substitutes for the material’s alcohol groups, thus providing elasticizing, moisturizing and anti-aging benefits for skin care.