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177 Results
Actives
Cosmetic Victories Finalist Profile: Penetrating Peptide for Enhanced ROS Elimination
Human eosinophil cationic protein was utilized as a carrier in this invention from ImDerma Laboratories to quickly penetrate skin cells and deliver high antioxidant efficacy with a low dose of EGCG.
Method/Process
Advanced Methods Measure Skin Penetrants at the Parts-Per-Billion Level
Healthy and intact skin was formerly considered an impermeable barrier designed to shield the living organism from all types of environmental injury, and certainly offering protection from all things chemical. Now skin is recognized as a semi-permeable membrane. Microorganisms cannot penetrate it, but it is pervious to chemicals, selectively allowing molecular passage in and out of the skin.
Literature/Data
Over the Top: Histone Deacetylase Inhibitors for Restorative Epigenetic Skin Care
The skin care industry has begun to explore epigenetics to ameliorate skin conditions. Within this field, histone deacetylase inhibitors (HDACis) are of interest thanks to their potent anti-inflammatory and other anti-aging effects. This article reviews their activity and utility.
Literature/Data
[podcast] How Nutrition Translates to Beauty, Part V: Epigenetic and Microbiome Factors
In relation to nutricosmetics, how does the microbiome come into play? What about epigenetics? This five-part podcast series with Zoe Diana Draelos, M.D., and Alan Dattner, M.D., considers the impact of nutrition on beauty. Here in part V, we consider these and other external factors.
Literature/Data
Patent Picks—Flavonoids, Genkwanin and Sakuranetin, Heat Shock Proteins and More
Chosen biweekly for their relevance to personal care, Patent Picks are taken from publicly available sources. This edition features patents related to anti-aging skin care technologies.
Method/Process
A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations
This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.
Event Coverage
Water Content, Nanoparticles and Skin Penetration in Brazil: Lindo Maravilhoso!
Water content, surfactants, thickeners, actives, nanoparticles and skin penetration were among the hot topics presented at the biennial XXI COLAMIQC congress of the Latin American and Iberian cosmetic chemists. Held May 14-16, 2013, in São Paulo, technical sessions were paired alongside the FCE Cosmetique exhibition and trade show for both the cosmetics and pharmaceuticals industries.
Literature/Data
Caprylyl Glycol/Phenethyl Alcohol Blend for Alternative Preservation of Cosmetics
In recent years, the safety of traditional preservatives has been called into question. Therefore, there is a need for alternatives that are effective, safe and sustainable—and that are non-controversial. In response, the present work investigates a mixture of caprylyl glycol and phenethyl alcohol, which is shown to provide antimicrobial activity in various skin and hair care formulations.
Actives
Elicitation of Rice Tissue Culture to Maximize Skin Epigenetic Modulation
Meristem cells of Himalayan red rice were cultured and elicited to produce secondary metabolites. Through an in vitro assay, rejuvenation was shown at the epigenetic level of treated cells. An increased expression of dermatopontin in keratinocytes, besides being a novel finding, implies that ReGeniStem™ Red Rice may be able to firm the skin and improve the skin barrier function.
Safety/Stability
Research Reviews Non-penetrating Sunscreen Vehicles, Looks to Jojoba
Several "carriers for the future" were highlighted, such as lipid carriers, cyclodextrin derivatives, encapsulation approaches and non-penetrating sunscreens incorporating UV filters and jojoba oil conjugates.
Cosmetic Ingredients
DNA Cosmetics Consortium Boosts Genetic Screening of Naturals: UPDATE
The consortium will provide models to the cosmetics/perfume sector to ensure the safety of plant raw materials and allow for better control of natural resources from the plant to the consumer.
Method/Process
Moisturizer Penetration in Skin Revealed via Low-coherence Inferometry
Research published in the Russian journal
Engineering
describes a method to measure the penetration of gel moisturizers in skin in vivo via low-coherence interferometry.
Actives
Garnet Continues to Develop Cell-based Therapy Platform for Skin Healing
The first in a series of cell products will be called GBT 009, and it will be capable of reducing inflammation and promoting healing.
Cosmetic Ingredients
Oleic Acid-induced Skin Penetration Effects of a Lamellar Delivery System
The structure and thermodynamic state of the skin’s lipid barrier are correlated with the skin’s penetration profile in this in vitro study using a delivery system composed of phospholipids, oleic acid, oil and water. Elevated percentages of oleic acid in the system affect the lipid barrier’s structure and thermodynamic properties...
SPF/Sun
[podcast] Sunscreen Innovation Act Update: MUsT Test and Penetration Potential
"What’s changed with respect to sunscreen evaluation is ... the test model they are using now is designed for drugs ...and has never been applied previously for the sunscreens," Epstein reports.
Colorant
Eckart Debuts Syncrystal Garnet High-Chroma Red, Bluish Undertone Pigment
"Our new addition fills the gap with more blue and less yellow, for a scarlet-red effect," the company reports.
Companies
Eligo Bioscience Patents Genetic Engineering of
Cutibacterium acnes
for Skin Therapies
The patent supports therapeutic interventions in serious skin disorders. This work provides opportunities to leverage the skin's immune system for oncological, vaccination or desensitization applications.
Method/Process
Advanced Methods Measure Skin Penetrants at the Parts-Per-Billion Level: Part II
Part I of this Dermatologic View column appeared in the January issue of
C&T
magazine and described advanced methods to measure skin penetration such as Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) and Atomic Absorption Spectrophotometry (AAS). Here, the authors continue this investigation of advanced methods to measure skin penetration.
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