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Section: Testing > Method/Process
Animal Alternatives
REACH and In Vitro Alternatives: Phototoxicity Testing
This is the third column in a continuing discussion regarding the new REACH regulations and their impact on chemical testing. The first appeared in December 2007 and discussed dermal corrosive potential testing; the second, in February 2008, covered dermal irritancy potential testing.
Method/Process
ATP Bioluminescence: Detecting Microbial Contamination in Dentifrices
In tests on eight dentifrice formulations, a bioluminescence system based on adenosine triphosphate (ATP) detected tested microorganisms qualitatively within 24-27 hours, compared to 5-7 days required for quantitative detection by standard methods.
Tech/Equipment/Services
Detecting Water Content in Deep Eutectic Solvents
Research appearing in the
Journal of Molecular Liquids
explores the use of ATR-IR spectroscopy to estimate the water content in natural deep eutectic solvents.
Method/Process
Inducing Hormesis for a Lipofilling-like Action
The present article discusses a new approach to mimic lipofilling—the activation of hormesis, which is accomplished by the described encapsulated active designed to induce a transitory stress and initiate an overcompensation to reestablish homeostasis. This leads to the compensation of age-induced lipoatrophy and correction of wrinkles and folds, for a younger-looking appearance.
Method/Process
The Safety Factor in Preservative Efficacy Testing
The authors explain how preservative efficacy testing is done to determine whether a formula is adequately preserved. Product contamination problems are frequently caused by inadequate preservation.
Literature/Data
Psoriasis Meets its Match in Vanilla Extract
What do baked goods and psoriasis have in common? Research in the
Journal of Agricultural and Food Chemistry
suggests that synthetic vanilla extract can topically treat the chronic condition.
Method/Process
[podcast] Senescence to Understand Aging in Hair
Aging is a common denominator across not just cultures but substrates. Here, Alison Pawlus, Ph.D., of Aveda, describes a test based on cell senescence to measure the effects of aging in hair and identify ways to mitigate them. Listen now!
Method/Process
ACS Analyzes Microscopic Views of Hair Interaction
The ACS announced at its 236th meeting that it has carried out a microscopic analysis of hair fibers interacting with each other. The researchers find that this information will be beneficial to cosmetic chemists who formulate hair repair products.
Safety/Stability
Truth in Exposure: Disparity Dictates Product Safety
How often do you relax your hair? or color it? Clearly, some consumers are exposed to given products more than others based on preferences or practices. A new study points to this fact as a crucial component for regulators to consider when determining ingredient safety.
Actives
Lightening Skin Through a Melanogenesis-interrupting Peptide
Cutaneous pigmentation is determined by melanogenesis, the transfer of melanosomes to keratinocytes, and the distribution of melanin to skin, among other processes. Interrupting these would limit skin pigmentation to achieve a better skin lightening effect. Here, the authors review the biological mechanisms of melanin production, then test a peptide designed to act on them for a lightening effect.
Method/Process
Genetic Test for Alopecia Approved in Europe
The HairDX Genetic Test for Hair Loss, a genetic baldness test manufactured by HairDX LLC, is now available as a CE Marked product under the European In Vitro Diagnostic Directive.
Method/Process
Detecting Coral Stress in Response to Sunscreens
Metabolomics is at the heart of recent work published in
Nature Scientific Reports,
wherein an increase in a known steroid in coral was noted in the presence of three common sunscreen ingredients.
Method/Process
Predicting the Percutaneous Penetration of Cosmetic Ingredients
While previous algorithms for predicting the skin absorption of permeants was based on in vitro data, the present article proposes a quantitative structure-activity relationship (QSAR) model based on in vivo human data. Here, a set of human in vivo data is described that provides entry into predicting the penetration of cosmetic ingredients.
Method/Process
CeeTox Expands In Vitro Capabilities with Acquisition
CeeTox has acquired assets of ADMETRx Inc. that allow it to expand its range of in vitro service offerings. Specifically, the acquired assets allow CeeTox to increase its existing Absorption, Distribution, Metabolism, Excretion (ADME) capabilities.
Method/Process
In Vitro Model for Decontamination of Human Skin
The present study utilized an in vitro model to compare the decontamination capacity of three model decontaminant solutions: tap water, isotonic saline and hypertonic saline. Human cadaver skin samples were dosed with radio-labeled [14C]-formaldehyde and the surface skin of each sample was washed after each exposure with one of the three model decontaminant solutions.
Literature/Data
Testing the Fate (and Exposure) of Cosmetic Ingredients
Risk and exposure go hand-in-hand. So when researchers dared to publish a new method to assess the exposure and fate of cosmetic ingredients, we couldn't help but give them exposure, in this review.
Method/Process
Testing Tactics in Skin: Evaluating Radiance and Texture
Hydrated, even-toned skin with a natural glow, all indicators of health, has gained popularity in the last decade. This article explores the meaning of skin radiance, its relationship to texture and various ways to measure this desired attribute.
Skin Care
Provital Group Launches Ingredient to Reduce Skin Shine
According to Google Trends, oily skin is the fourth prominent cosmetic concern. In response to this consumer concern, Provital Group created an ingredient inspired by the purity of lotus to calm the skin and remove shine and impurities.
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