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Iontophoresis is a well-known, noninvasive method that uses a small electric charge to deliver chemicals through the skin. However, according to Gregory Schultz, PhD, and Daniel Gibson, a professor and doctoral candidate, respectively, at the University of Florida, this method of delivery can have its drawbacks. Together with co-inventor, Sonal Sanjeev Tuli, MD, the team developed a method to iontophorese macromolecules into tissue such as the skin without causing damage; however, initial research focused on the eye.