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Section: Research > Literature/Data

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EpigenCare Offers Personalized Skin Care via Epigenetics

The company matches consumers to existing skin care products based on their epigenetic profile and skin quality indicators, including aging and DNA damage.

Validating the Effectiveness of Rubbing on Percutaneous Penetration

The effect of rubbing on percutaneous penetration has long been questioned. Existing data regarding rubbing effects is sparse, and what is available is controversial at best. While some evidence suggests that rubbing increases absorption, others note the opposite. Further understanding of the rubbing effect on percutaneous penetration may offer a more complete picture in relation to the application of drugs, cosmetics and skin care.

Penetration of Cosmetics Into and Through the Stratum Corneum

The penetration routes of substances through the stratum corneum and how these transport pathways function are becoming better understood. Despite this progress, however, the penetration mechanisms of cosmetic formulations remain mysterious. This overview presents current knowledge on the various pathways of penetration, and suggests that even if cosmetic formulations penetrate no deeper than the surface, their efficacy may still be optimal.

Skin Antioxidants

The skin is supplied with an antioxidant defense system that includes enzymatic and nonenzymatic components.

Rapid Electrokinetic Patterning for Biological Analysis, Nanoassembly

Researchers at Purdue University have developed a rapid electrokinetic patterning technique using a laser and holograms to quickly position tiny particles for biological analyses or to create devices using nanoassembly.

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Epigenetics and Aging: A New Player in Skin Care

The cosmetics and skin care industry is constantly developing new products and technologies that aim to slow down the skin aging process. Epigenetic processes play an important role in skin aging. Several new cosmetic products target epigenetic mechanisms and have shown promising results as novel cosmeceuticals.

Penetration of Cosmetics Into and Through the Stratum Corneum

The penetration routes of substances through the stratum corneum and how these transport pathways function are becoming better understood. Despite this progress, however, the penetration mechanisms of cosmetic formulations remain mysterious. This overview presents current knowledge on the various pathways of penetration, and suggests that even if cosmetic formulations penetrate no deeper than the surface, their efficacy may still be optimal.

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Lipotec’s Peptide Regenerates Skin Using Epigenetics

Lipotec has launched PEPROAGETM peptide, which assists in leaving skin smoother, more radiant and visually rejuvenated. The peptide can be incorporated into any anti-aging formulation to help reduce skin regeneration taking place with age or in products designed to rejuvenate the skin.

Biobank Project Initiated for Genetics, Disease Studies

Funded by the Wellcome Trust, the Medical Research Council, the Department of Health and the Scottish Executive, the study is designed to examine the interaction of genes, environment and disease in half a million people.

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P&G, 23andMe Uncover Genetic Ties to Sensitive Skin

Research from P&G and 23andMe reveals new genetic associations underlying sensitive skin syndrome.

Formulating Focus: The Influence of Emollients on Skin Penetration

This column will discuss ways in which ingredients can positively affect the partition coefficient of the active between the formula and the skin. By carefully selecting the emollients used in a formulation, formulators can increase the delivery and clinical efficacy of a formulation without increasing the level of the active ingredient.

Formulating Focus: The Influence of Emollients on Skin Penetration

This column will discuss ways in which ingredients can positively affect the partition coefficient of the active between the formula and the skin. By carefully selecting the emollients used in a formulation, formulators can increase the delivery and clinical efficacy of a formulation without increasing the level of the active ingredient.

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The Genetic Relation Between Skin Tanning and Burning

Scientists recently investigated whether or not genetics can be linked to the propensity of skin to burn or tan, and how this connection may also explain people at risk to skin cancer.

The flutamide plus minoxidil solution was significantly more effective than minoxidil.

Flutamide Enhances Efficacy of 5% Minoxidil in Androgenetic Alopecia

Topical flutamide plus minoxidil solution was significantly more effective than minoxidil in improving hair density, hair thickness and patient satisfaction.

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Patent Pick: Conjugated, Penetrating Botulinum Toxin

Patent Picks are chosen by the editors from publicly available sources. Today's patent relates to a cell-penetrating peptide fused to a botulinum toxin recombinant protein, for cosmetic and other purposes.

Assessing the Safety of Parabens: Percutaneous Penetration and Risk Analysis

In cosmetics, parabens are widely used due to their low cost and efficacy. In recent years, however, some reports have claimed that these materials exhibit estrogenic activity, which has led to attempts to replace them in formulations. This article reviews penetration studies of parabens spanning the past 20 years to determine whether they pose a risk to human health.

Study Uncovers Genetic Predispositions to Skin Cancer

Basal cell carcinoma is the most common cancer worldwide, with an annual incidence of 2.8 million cases in the United States alone. A recent study found 31 genetic markers for the disease, 14 of which were identified for the first time.

A Dermatological View—Percutaneous Penetration of Amino Acids

Skin care products containing amino acids often promote the benefits conferred on the skin by these molecules. Natural amino acids found in the skin have been found to improve the health of skin through antioxidation, membrane stabilization and increasing skin’s natural moisturizing factor (NMF).

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