According to a study published in Pharmaceutics, restoring hair follicles by inducing the anagen (growth) phase is a promising approach to prevent hair loss. In relation, the therapeutic effect of Morus alba root extract on hair growth was explored.
Hair follicle dermal papilla cells were treated with M. alba root extract at 20%, which was initially confirmed as non-cytotoxic. This concentration was shown to successfully enhance growth factor secretion related to the telogen-to-anagen transition; the authors noted high concentrations of chlorogenic acid and umbelliferone in the extract.
The increased expression of growth factors was due to the activation of β-catenin. According to the authors, this study elucidated the molecular mechanisms underlying the telogen-to-anagen transition induced by the extract.
See archived: Approaches to and Characterization of Hair Growth