Hyaluronic Acid Intensified: Cross-linking Improves Stability, Functionality


Hyaluronic acid (HA) is well-known for the benefits it provides in topical formulations, including moisturization, delivery of water and actives to the skin, film formation and antioxidant effects.1-4 HA also is critical to the functional well-being of normal physiological processes of the skin;5-7 notably protection via said antioxidant effects, hydration, stabilization of the tissue matrix structure and cellular repair.8-12 Its linear structure consists of repeating dimers of N-acetyl glucosamine and Na-D-glucuronate, which are linked together to form a long, unbranched chain having a high molecular weight (HMW) of 2-4 ×106 Da.13 HMW HA chains form hydrated random coils, which interact to produce highly viscoleastic solutions.14

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