Patent Picks—Venus Flytrap, Cross-linked Silk, Wax Plant and More for Anti-aging and Skin Repair

Patent Picks are compiled by the editors from publicly available sources. This edition features recent inventions related to lifting, antioxidants, delivery, collagen production, density and more for anti-aging and skin repair.

Venus flytrap for skin-lifting effects
U.S. Patent Application 20140308222
Publication date: Oct. 16, 2014
Assignee: Quantum Pharmaceuticals Ltd., and the Royal Government of Bhutan, Ministry of Agriculture

This patent describes an extract of Dionaea muscipula (Venus flytrap) and a composition incorporating it for the treatment of changes in skin and skin appendages due to accelerated or chronological aging; e.g., wrinkles, loss of firmness and elasticity, and increased pigmentation. According to the inventors, Venus flytrap has surprisingly been found to re-shape cellulite, sagging skin and stretch marks (striae) by inducing a strong lifting effect.

Cross-linked silk and hyaluronic acid for skin repair
U.S. Patent Application 20140315828
Publication date: Oct. 23, 2014
Assignee: Allergan Inc.

Disclosed herein are compositions for use, for example, as dermal fillers or to facilitate adipose tissue transfer and grafting procedures, and methods for using them. The fillers comprise silk attached to hyaluronic acid by two cross-linkers. The compositions include a gel phase wherein the silk fibroin hydrogel component and matrix polymer hydrogel are processed separately. These materials are then mixed together, such as after a milling step and/or after re-homogenization in a carrier phase, to form the final composition. The composition may be administered by syringe with a needle, catheter, topically or by direct surgical implantation.

Ultrasound delivery of nanoparticles
U.S. Patent Application 20140316387
Publication date: Oct. 23, 2014
Inventors: TJ Harris, K Chen and A Alice

The present invention discusses enhancing the delivery of skin treatment compositions using photoactive plasmonic nanoparticles and light. In several embodiments, laser or light energy is used in conjunction with nanoparticles and/or photoactive compounds to treat skin, including tissue under the skin surface, to modify, smooth, and/or resurface it. Other embodiments relate to methods for focusing electromagnetic energy to selectively heat target regions of skin, as well as applications for the treatment of acne and acne scars, without damaging surrounding skin tissue.

Vitamin C, vitamin E and polyphenol antioxidant composition
U.S. Patent Application 20140315995
Publication date: Oct. 23, 2014
Inventor: F Dreher

According to this inventor, there is a need for stable, topical compositions having improved and/or superior antioxidant activity that are suitable for topical application and/or administration. As such, disclosed herein are non-irritating, stable topical compositions including at least vitamin C, vitamin E and a polyphenol antioxidant to facilitate the prevention or treatment of free oxygen, nitrogen and/or other free radical-related skin damage.

Anti-convulsive for skin repair
U.S. Patent Application 20140315991
Publication date: Oct. 23, 2014
Inventors: NA Shapira and A Barzilay

The present inventors have discovered that topical formulations of a gamma-aminobutyric acid (GABA) agonist, specifically o/w based formulations of the anti-convulsive drug topiramate, are effective in reducing the healing time of excisional and incisional woundsand reducing or eliminating subsequent fresh scarring. In addition, topical topiramate formulations were found to be effective in improving dermatological diseases, skin barrier diseases, autoimmune skin diseases, steroid-induced skin atrophy and striae, skin aging and related disorders.

Antioxidant, anti-inflammatory short peptides
U.S. Patent Application 20140315787
Publication date: Oct. 23, 2014
Inventors: J Mograbi, D Atlas and S Keynan

Described by this patent are potent short peptides having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties and their clinical and cosmetic applications. According to the inventors, there is an unmet need for improved compositions directed to the prevention and treatment of damage caused by ionizing radiation that are suitable for oral, topical and systemic administration. Further, it would be beneficial to have antioxidant, anti-inflammatory, anti-allergy and metal chelating compounds that combine high potency, good stability and bioavailability with a sufficient half-life to achieve the desired effects. The present invention addresses these needs.

Hoya carnosa (wax plant) extracts for collagen production
US Patent 8865231
Publication date: Oct. 21, 2014
Assignee: Avon Products, Inc.

Disclosed herein are extracts of Hoya carnosa (wax plant) for anti-aging and reparative benefits. According to the inventors, Hoya carnosa extracts have surprisingly been found to increase collagen production, thicken the epidermis and stimulate lipid production (lipogenesis) in the skin. Such compositions are suitable for the treatment and prevention of the loss of facial volume to counteract sagging skin, wrinkles and the like.

Plantago lanceolata (plantain) stem cells for skin density, firmness
WIPO Patent Application WO/2014/167464
Publication date: Oct. 16, 2014
Assignee: Sederma and I.R.B. Istituto di Recerche Biotecnologiche

According to the invention, meristematic cells obtained from Plantago lanceolata (plantain) can be used in cosmetics for anti-aging, nutraceutical or dermatological applications. Plantago lanceolata, a perennial plant of the Plantaginaceae family, is also referred to as plantain, ribwort plantain, ribgrass, ripple-grass, English plantain, buckhorn plantain, narrowleaf plantain, lanceleaf plantain, ribleaf and lamb's tongue. This extract was found, in vivo, to improve dermis quality in terms of firmness, elasticity and thickness, among other benefits. Specifically, it is indicated to densify the dermis, strengthen the dermal-epidermal junction, thicken the epidermis and/or provide anti-glycation defense to skin.

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