Innovation in cosmetics often begins with nature. In a remarkable scientific milestone, LipoTrue identified a previously unknown marine microorganism, Alteromonas lipotrueae, isolated from the surface of the Mediterranean jellyfish Pelagia noctiluca. This discovery led to the development of a novel marine ferment and marks the first vertically integrated cosmetic active ingredient developed by the company, from strain identification to final ingredient delivery.
The discovery of A. lipotrueae represents more than the identification of a new bacterial species. Through genomic analysis and scientific validation, the microorganism was officially characterized and deposited in international culture collections, contributing to the global scientific community. Its discovery was published in Systematic and Applied Microbiology in 2021.
Following its identification, extensive exometabolomic studies revealed that the ferment produced by A. lipotrueae contains biomimetic compounds capable of influencing neuron-muscle communication pathways while also providing anti-aging benefits. Gene expression studies demonstrated modulation of genes involved in neuritogenesis, synaptic transmission, and muscular contraction.
The marine ferment acts through a holistic neurocosmetic approach targeting the mechanisms responsible for expression lines. Research showed a reduction in neurite growth and neuronal migration, limiting the formation of neuromuscular junctions. In addition, the ferment decreased clathrin levels and acetylcholine release, key processes involved in synaptic vesicle recycling and muscle stimulation. These effects ultimately contributed to a reduction in muscular contraction activity associated with facial expressions.
Beyond its neuromodulating activity, the ferment also demonstrated complementary anti-aging properties. In vitro studies showed increases in hyaluronic acid production and procollagen I synthesis, supporting skin hydration and firmness.
These scientific findings were further validated in clinical studies involving women aged 45 to 60 with visible expression lines. Volunteers applied a cream containing 3% of the marine ferment twice daily for 28 days. Results were observed both immediately and over time. After only 10 minutes, significant reductions in wrinkle volume and depth were recorded in crow’s feet and forehead expression lines. Long-term use produced even greater improvements, with wrinkle depth reduced by up to 35% and wrinkle volume by up to 35% in certain facial expressions.
Particularly noteworthy was the ferment’s ability to reduce so-called “hidden wrinkles,” the additional wrinkles that appear during smiling or frowning. Clinical measurements demonstrated a visible reduction in these dynamic wrinkles, helping the skin maintain a smoother appearance even during facial movements.
The marine ferment derived from Alteromonas lipotrueae introduces a new generation of neurocosmetic actives by addressing the biological communication between neurons and muscles. Through its combined effects on neuromuscular signaling, skin structure, and visible wrinkle reduction, it offers a comprehensive solution for expression lines and represents a significant advancement in cosmetic science.
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