Native Extracts has partnered with Nutrafruit to deliver an ingestible and topical product under the Queen Garnet brand, which can be formulated in cosmetics, nutraceuticals, pharmaceuticals, foods and beverages.
The topical, Queen Garnet Cellular Extract (INCI: Prunus Salicina Fruit Extract), is said to harness the water-soluble phyto-compound profile of the natural ingredient and its derivatives to provide an array of benefits. The Queen Garnet Fruit Essence ingestible employs extraction protocols designed by the company’s nutraceutical team to release levels of nutrients through highly concentrated, solvent-removed liquid essences.
"A lot of our aging-related decline in metabolism is correlated with reducing levels of NAD, and both cyanidin and quercetin have shown potential for restoring our NAD back to youthful levels."
More specifically, the extracts contain phyto-compounds including anthocyanins such as cyanidin-3-glycoside, chlorogenic acid, rutin, epicatechin, quercetin and more. Anthocyanin is reportedly known to have antioxidant, antimicrobial and anti-inflammatory effects.
Regarding anthocyanin and quercetin, a growing body of research suggests this combination is worth exploring, according to Native Extracts’ senior biotechnology and nutrition specialist, Evan Stephens, Ph.D.
“The cyanidin and quercetin-based flavonoids present in extracts of Queen Garnet may have benefits in skin health,” explained Stephens. “. . .these flavonoids and their glycosides have potent anti-inflammatory properties. Whilst exerting their strong antioxidant effects, [it was found they] can support the metabolism in the mitochondria where much of the reactive oxygen species (ROS) are generated. They can also more broadly influence mitochondrial function and even mitochondrial biogenesis."
Stephens continued: "A lot of our aging-related decline in metabolism is correlated with reducing levels of NAD (nicotinamide adenine dinucleotide), and both cyanidin and quercetin have shown potential for restoring our NAD back to youthful levels. This occurs through the inhibition of enzymes that break down NAD (NADases), which highlights the potential for pairing these flavonoids with the common dermatological ingredient nicotinamide (vitamin B3).
"In the past decade and even now, there have been numerous studies that showed these flavonoids do permeate the stratum corneum and can achieve adequate levels in the epidermis and the dermis of the skin, satisfying the kinetic parameters of release from topical emulsions and penetration into the metabolically active layers of the skin.”
“Through the trialing process of R&D design, ... we narrowed the first phase of commercialization to two variants specific to topical and ingestible applications, and have further concepts to leverage the fruit’s potential in the future,” said Lisa Carroll, managing director at Native Extracts. “It’s already in trials for skin care applications and moving to hair, scalp and oral care projects next.”