Recent in In vitro (page 8 of 11)

Microscopic Scaffolding for Wound Healing, Toxicity Testing

The UK-based EPSRC announced the development of a dissolvable scaffold to grow skin tissue that could offer a new method to treat wounds, as well as possibilities for toxicity testing of cosmetics.

Measuring the Antioxidant Potential of an Acai Extract

The antioxidant potential of cosmetic materials can be evaluated by several methodologies, including a commercial kit that measures total antioxidant status, as illustrated here with a commercial extract from the fruit of the açaí, a Brazilian palm tree. Applications in antiaging products are suggested.

Three Decades of Patch Testing: Trends in the North American Populace

This report evaluates the trends in the results of patch testing. The patch test reactions were surveyed retrospectively. The results were statistically compared between 1970 and 2002 because appropriate interpretation of the numbers has public health opportunities.

Testing Tactics: REACH and In vitro Alternatives: Skin Irritation Testing

Welcome back to a continuing discussion regarding the new Registration, Evaluation and Authorization of Chemicals (REACH) regulation and its impact on chemical testing. It is the purpose of this series of articles to provide an overview of these existing validated in vitro methods, as well as new methods that are being considered for validation.

Texture Analysis to Quantify Skin Care Product Efficacy

Using a texture analyzer to measure the tightness of the skin before and after the application of selected treatments, the authors demonstrate the potential of texture analysis instrumentation in testing the efficacy of skin care products and substantiating skin tightening claims.

In Sight—QOL Testing: Complementing Clinicals

Personal care efficacy tests are known to test the physical effects or toxicity of products, often omitting more abstract and possibly equally as important factors such as well-being.

Rheological Characterization of a Modified Taurate Acrylic Polymer for Skin Care

The rheology of a pre-neutralized, hydrophobically modified acrylic polymer was investigated by dynamic mechanical measurements using this methodological approach to establish its viscoelastic profile and stability in formulations. Properties of several polymer-containing emulsions were studied and their particle size distribution investigated by laser diffraction.

With the Speed of Light: A Look at Accelerated Testing

We test a number of things in our cosmetic industry. We test for safety; for stability; for efficacy; for microbiological contamination; and for interactions between the (ingredients of the) product and its container.

Preservative Efficacy Testing: Accelerating the Process

A preservative efficacy testing method, called accelerated double challenge, rapidly—in 14 days—assesses the ability of a product or material to resist microbial contamination. It also maintains a high degree of correlation with longer-term preservative challenge protocols.

A Dermatological View—Squamometry: An Early Predictor of Changes in the Skin Barrier

Squamometry is useful in identifying the low or subclinical irritation potential of substances even before any change in the TEWL can be measured.

Testing Tactics: In Vitro Approaches to Antiaging Testing

Using proper methods, it is possible to screen materials for potential antiaging effects; in turn, these materials can be incorporated into cosmetic or personal care products. To properly screen antiaging materials, all that is required is a basic understanding of the aging process.

Texture Analysis to Select Packaging and Formulate Hair Care Products

Texture analysis provides quantitative information about a material’s response when deformed by a controlled force. Examples illustrate the use of a texture analyzer to evaluate shampoo extrusion, hair spray film toughness, hair spray tackiness, styling wax hardness and aerosol canister deployment.

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