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Recent in In vitro (page 3 of 6)

IBN Engineers Hair Follicle Model for Development of Anti-hair loss Actives

The Institute of Bioengineering and Nanotechnology (IBN) has recently engineered a new hair follicle model that could help discover new drugs or active ingredients for hair regeneration.

Rapid Colorimetric Analysis of para-Phenylenediamine in Henna-based, Non-permanent Tattoo Color Mixtures

In some henna mixtures, para-phenylenediamine (PPD) has illegally been added and it is responsible for complications such as allergic contact dermatitis. While high-performance liquid chromatography has previously been used to detect PPD, a colorimetric method that is faster and portable, described here, has been developed. For product developers, this method can be used to evaluate henna plant extracts.

In Sight—QOL Testing: Complementing Clinicals

Personal care efficacy tests are known to test the physical effects or toxicity of products, often omitting more abstract and possibly equally as important factors such as well-being.

Responsilbilities in Outsourcing Clinical Testing

It remains the responsibility of the manufacturer to substantiate the safety of both ingredients and finished cosmetic products prior to their being marketed.

‘How Did THAT Get in There?’ Identifying Particulate Contamination in Products and Packaging

Particulate contamination and discoloration may occur in products due to foreign materials introduced via raw materials or during the manufacturing process. Agglomeration or reactions between ingredients and packaging components also are possible sources. The identification of contaminants and their origin, described here, is therefore critical so that future incidents can be prevented and safety or regulatory concerns can be addressed.

Evaluating Water Permeability and Occlusion in Wound Dressings and Topical Cosmetics

The present study uses an evaporimeter to measure the degree of water loss from in vitro skin samples covered by occlusive and semi-occlusive wound dressings to serve as a model for determining the effectiveness of occlusive cosmetic formulations. The purpose of this work was to develop a model for determining the effectiveness of occlusive cosmetic formulations.

DNA: Hard Evidence of Cosmeceutical Claims

To support finished product or raw material claims these two in vitro methods—the Affymetrix microarray and the Taqman Real Time Polymerase Chain Reaction (PCR)—measure the up-regulation or down-regulation of genes.

In Vitro Model for Decontamination of Human Skin

The present study utilized an in vitro model to compare the decontamination capacity of three model decontaminant solutions: tap water, isotonic saline and hypertonic saline. Human cadaver skin samples were dosed with radio-labeled [14C]-formaldehyde and the surface skin of each sample was washed after each exposure with one of the three model decontaminant solutions.

Fluorescence LSCM to Assess the Penetration of Low Molecular Protein Hydrolyzates Into Hair

The present study uses confocal laser scanning fluorescence microscopy to assess the penetration of protein hydrolyzates into hair. While higher amounts of protein were found in the cuticle, still significant quantities were observed in the cortical parts of hair, and this penetration was enhanced by longer incubation times.

A Review of Genomic Techniques in Cosmetics Testing

Genomics assists product developers in understanding the expression of specific genes and their relationship to particular skin attributes. This article reviews commonly used testing techniques, such as DNA microarray, RT-PCR, SAGE, northern blot and RNA sequencing, and describes their application in testing the effects of cosmetic ingredients and products on skin.

Assessing the Impact of Hair Damage Types on Color Retention

This article reviews and assesses damage types caused to hair before and after artificial coloration, i.e., by bleaching, perming, heat treatment, UV exposure and shampooing, to compare how they impact color durability individually and combined. Formulation emerges as the key to designing shampoos that efficiently deliver actives to improve color protection against these and other damage types.

Assessing the Impact of Hair Damage Types on Color Retention

This article reviews and assesses damage types caused to hair before and after artificial coloration, i.e., by bleaching, perming, heat treatment, UV exposure and shampooing, to compare how they impact color durability individually and combined. Formulation emerges as the key to designing shampoos that efficiently deliver actives to improve color protection against these and other damage types.

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