Recent in In vitro (page 2 of 5)
Oct 27, 2013
Manufacturers of topical products perform rigorous testing to assure that their products are safe for consumers. Of particular interest is determining whether products will irritate the skin of the approximately 50% of consumers surveyed who consider themselves to have “sensitive” skin.
Oct 24, 2013
The antioxidant potential of cosmetic materials can be evaluated by several methodologies, including a commercial kit that measures total antioxidant status, as illustrated here with a commercial extract from the fruit of the açaí, a Brazilian palm tree. Applications in antiaging products are suggested.
Oct 1, 2013
Botanical ingredients are interesting for their unique and complementary chemical diversities yet they are criticized for these very traits, which make quality assurance, reproducibility and good phytochemical characterization—required for successful high throughput screening, difficult. This article discusses these challenges as well as the benefits of large-scale screenings of botanical extracts that are currently used or developed for cosmetic product development.
Aug 22, 2013
Endocrine disruptor chemicals (EDCs) are a class of chemicals that has raised alarm for being linked to a wide variety of detrimental effects on human and wildlife populations, e.g., cancers, precocious puberty and obesity. Thus, there is a need to test personal care products and supplements for EDCs, which can be accomplished using the validated bioassay described here.
Aug 8, 2013
Here, the author compares two methods to determine the maturity of corneocytes based on their cross-linking that could be used to evaluate the anti-aging effects of molecular agents. The first utilizes microfluorometry, while the second involves F-D curves generated via contact mode AFM. Both methods successfully detected differences in mature or immature corneocytes with 95% confidence.
Aug 8, 2013
Welcome back to a continuing discussion regarding the new Registration, Evaluation and Authorization of Chemicals (REACH) regulation and its impact on chemical testing. It is the purpose of this series of articles to provide an overview of these existing validated in vitro methods, as well as new methods that are being considered for validation.
Aug 7, 2013
It should perhaps go without saying that consumer products are sold using consumer language. Market researchers and consumer scientists spend a great deal of time studying their target audience and learning this vocabulary, which subsequently allows the recounting of product benefits in the same terminology.
Aug 7, 2013
The Institute of Bioengineering and Nanotechnology (IBN) has recently engineered a new hair follicle model that could help discover new drugs or active ingredients for hair regeneration.
Rapid Colorimetric Analysis of para-Phenylenediamine in Henna-based, Non-permanent Tattoo Color Mixtures
Jul 17, 2013
In some henna mixtures, para-phenylenediamine (PPD) has illegally been added and it is responsible for complications such as allergic contact dermatitis. While high-performance liquid chromatography has previously been used to detect PPD, a colorimetric method that is faster and portable, described here, has been developed. For product developers, this method can be used to evaluate henna plant extracts.
Jul 12, 2013
Personal care efficacy tests are known to test the physical effects or toxicity of products, often omitting more abstract and possibly equally as important factors such as well-being.
Jul 10, 2013
It remains the responsibility of the manufacturer to substantiate the safety of both ingredients and finished cosmetic products prior to their being marketed.
Jun 25, 2013
Particulate contamination and discoloration may occur in products due to foreign materials introduced via raw materials or during the manufacturing process. Agglomeration or reactions between ingredients and packaging components also are possible sources. The identification of contaminants and their origin, described here, is therefore critical so that future incidents can be prevented and safety or regulatory concerns can be addressed.