Recent in Testing (page 17 of 20)

Evaluating 1,3-Propanediol for Potential Skin Effects

In the present article, the authors assess the skin irritation and sensitization potential of 1,3-propanediol (INCI: Propanediol). Results in animals and humans by acute or repeat exposure support a low potential of skin reactivity for the material. In addition, the skin reactivity potential in humans was found to be lower with 1,3-propanediol than 1,2-propanediol (INCI: Propylene Glycol).

Predicting the Percutaneous Penetration of Cosmetic Ingredients*

While previous algorithms for predicting the skin absorption of permeants was based on in vitro data, the present article proposes a quantitative structure-activity relationship (QSAR) model based on in vivo human data. Here, a set of human in vivo data is described that provides entry into predicting the penetration of cosmetic ingredients.

Microfluidic Testing for LLNA Replacement

The Hurel Corp. has developed a microfluidic, non-animal alternative to the LLNA and it has partnered with L’Oréal to make this approach a reality—in the form of a chip.

Mechanisms of Tape Stripping and Protein Quantification*

In this article, several methods to quantify the protein collected by tape stripping are described, including traditional gravimetric methods as well as novel colorimetric and visible spectroscopic techniques. Further, one colorimetric method is described to effectively determine the keratolytic efficacy of various materials in vivo, suggesting additional roles for this method.

A Rapid and Sensitive In vitro Method to Ascertain Antioxidative Capacity*

New methodologies have recently been developed to determine antioxidant effects but they often require extensive training and are time-consuming to conduct. In the present article, however, the authors describe an in vitro method to detect the effects of antioxidant-containing formulations using photochemiluminescence to provide rapid, accurate and sensitive measurements.

Researchers Develop Non-animal, Dendritic-based Sensitizer Test

Researchers from the University of Aveiro, the University of Coimbra and the University Hospital of Coimbra have developed a dendritic cell-based test for skin sensitizers that can serve as an alternative to animal testing.

Beiersdorf Researcher Develops Skin Imaging Method for Analysis

Beiersdorf has created a new method of skin analysis to help it develop new skin care products.

A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations

This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.

Influence of Skin Diffuse Reflectance on Sun Damage and Ingredient Efficacy Measurements

Current in vitro methods to assess photostability and antioxidant activity do not account for the diffuse reflectance of skin. Described here is an in vitro test that addresses this variable, mimics end-use product conditions and models photodamage processes. The approach is employed to determine the efficacy of an antioxidant from the Camellia sinensis (tea) plant.

Hair Ethnicity and Ellipticity: A Preliminary Study

Ethnic hair care addresses diverse fiber compositions that require unique products. This comprehensive review in hair fiber dimensions among straight, wavy and curly/coily hair serves as a basis from which product developers can design products to cater to unique hair type needs. The current study examines the ellipticity of Caucasian, Brazilian, Hispanic and African-American hair.

Hair Ethnicity and Ellipticity: A Preliminary Study

Ethnic hair care addresses diverse fiber compositions that require unique products. This comprehensive review in hair fiber dimensions among straight, wavy and curly/coily hair serves as a basis from which product developers can design products to cater to unique hair type needs. The current study examines the ellipticity of Caucasian, Brazilian, Hispanic and African-American hair.

Adjusting Substrate/Product Interfacial Properties to Improve In vivo/In vitro SPF Correlation

This work evaluates the impact of a plasma treatment on test substrates to modify their surface energy, to more closely correlate in vitro SPF measurements with in vivo measurements—without chemically altering the test products. The authors chose the level of plasma modification to use on a substrate based on in vivo values; they explain how to choose it regarding specific formulas in a further paper.

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