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Aug 31, 2007 | 11:32 AM CDT
By: C. Lenaers, D. Boudier, V. Barruche and B. Clo…
The authors describe a model to visualize the appearance of cyclobutane-pyrimidine dimers in the nuclei of normal human keratinocytes after UV irradiation. These dimers are one of the principal agents in DNA damage. The model can be used to assess the effect of a cosmetic ingredient on the formation of direct UV-induced lesions to DNA.
Aug 03, 2007 | 09:09 AM CDT
The European Centre for the Validation of Alternative Methods (EVCAM) has released its 61st report of a series of workshops.
Jun 07, 2007 | 09:47 AM CDT
The US National Toxicology Program (NTP), Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) has requested comments, nominations of scientific experts and submission of data on the murine local lymph node assay.
May 09, 2007 | 10:01 AM CDT
A framework has been established between the European Union (EU) and the United States that is expected to produce greater cooperation in the cosmetic and personal care industry.
May 03, 2007 | 09:48 AM CDT
Colipa announced yesterday that The European Centre for the Validation of Alternative Methods (EVCAM) scientific committee now endorses new safety test methods that eliminate animal testing.
Apr 30, 2007 | 03:35 PM CDT
By: Jo Smewing Stable, Micro Systems Ltd. and Janu…
Texture analysis provides quantitative information about a material’s response when deformed by a controlled force. Examples illustrate the use of a texture analyzer to evaluate shampoo extrusion, hair spray film toughness, hair spray tackiness, styling wax hardness and aerosol canister deployment.
Apr 30, 2007 | 03:29 PM CDT
By: Nancy E. Kinkade, PhD, Eastman Chemical Co.
Several signs of skin aging have been attributed to the presence of free radicals. This paper discusses the application of two-photon fluorescence microscopy to determine the effects of sample formulations on the number of reactive oxygen species (ROS) formed in skin models.
Apr 30, 2007 | 01:23 PM CDT
By: Robert Holtz, BioInnovation Laboratories
Several interesting and promising approaches to in vitro skin sensitization testing are in development. Perhaps it will not be long before they are deemed valid and reliable alternatives to animal testing.
Apr 02, 2007 | 11:01 AM CDT
By: Cornelia Huber, Thomas Schreier, Pentapharm Lt…
Plants living under extreme conditions have developed a strategy to protect their DNA and other important cell structures from environmental stress factors. In particular, watermelon (Citrullus lanatus) has adapted well to extreme conditions. Its survival strategy can be used in the field of skin care, as shown by several tests including a direct DNA protection assay, the COMET assay and 8-oxo-guanosine and p53 detection.
Mar 27, 2007 | 04:55 PM CDT
Skin penetration is of great interest to personal care formulators for many reasons. Following are a few recent findings.