Recent in Testing (page 16 of 32)

A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations

This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.

Influence of Skin Diffuse Reflectance on Sun Damage and Ingredient Efficacy Measurements

Current in vitro methods to assess photostability and antioxidant activity do not account for the diffuse reflectance of skin. Described here is an in vitro test that addresses this variable, mimics end-use product conditions and models photodamage processes. The approach is employed to determine the efficacy of an antioxidant from the Camellia sinensis (tea) plant.

Adjusting Substrate/Product Interfacial Properties to Improve In vivo/In vitro SPF Correlation

This work evaluates the impact of a plasma treatment on test substrates to modify their surface energy, to more closely correlate in vitro SPF measurements with in vivo measurements—without chemically altering the test products. The authors chose the level of plasma modification to use on a substrate based on in vivo values; they explain how to choose it regarding specific formulas in a further paper.

The Effect of Skin Metabolism on the Absorption of Chemicals

Skin expresses enzymes that can metabolize endogenous molecules but little is known regarding how they impact the delivery of xenobiotics. This review of recent works shows that skin metabolism alters the dermal absorption of lipophilic compounds, which opens new areas of investigation regarding the safety and efficacy of topically applied cosmetics.

Consumer Perception of Fine Lines and Wrinkles Assessed by Qualitative Methods

There are varying definitions, associations and overall impressions of fine lines and wrinkles among different consumer segments. The findings of this study offer invaluable insight into consumers’ opinions, and by qualitative in-depth interviews, they provide a well-defined vernacular for aging descriptors. This language is critical for developmental research, consumer evaluation and marketing within the cosmetic industry.

Shiseido Develops Method Using Spectrometry to Display Skin Permeation

Shiseido has developed a method to assess the skin permeation of cosmetic ingredients using a novel spectrometry technology.

Appointment of Commissioner Borg May Jeopardize Animal-alternative Test Progress

Cosmetics Europe recently urged the industry to oppose the appointment of Tonio Borg as Health Commissioner, as his "commitment to conclude the introduction of the March 2013 [animal testing] ban without addressing scientific reality or consumer needs is a great concern."

Determining Korean Consumers’ Degree of Exposure to Lipstick and Face Creams

This study describes methods used in a Korean study to calculate consumer exposure to lipstick and face creams. The average amount applied daily was estimated and compared with data collected by weighing containers before and after use. The data collected was 1.8 to 1.6 times greater than the estimate, so although the survey represented real use patterns, the actual data was more accurate.

'Land'scaping-Ho!

For the current picture, Cosmetics & Toiletries knows many of the headaches you endure; for example, regulations and scale-up. It would take volumes to address all the challenges these pose, but this issue covers two specific aspects of them.

‘How Did THAT Get in There?’ Identifying Particulate Contamination in Products and Packaging

Particulate contamination and discoloration may occur in products due to foreign materials introduced via raw materials or during the manufacturing process. Agglomeration or reactions between ingredients and packaging components also are possible sources. The identification of contaminants and their origin, described here, is therefore critical so that future incidents can be prevented and safety or regulatory concerns can be addressed.

Determining Korean Consumers’ Degree of Exposure to Lipstick and Face Creams

This study describes methods used in a Korean study to calculate consumer exposure to lipstick and face creams. The average amount applied daily was estimated and compared with data collected by weighing containers before and after use. The data collected was 1.8 to 1.6 times greater than the estimate, so although the survey represented real use patterns, the actual data was more accurate.

Using In vivo and In vitro Testing for Evidence-based Development of Anti-aging Ingredients

The need for a conceptual approach to skin aging, the need to combine in vitro and in vivo findings and the new direction for cosmetic ingredient manufacturers are discussed here.

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