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Patent Picks—Zebra Fish Peptides, Functionalized Adjuvants, Co-jetting and More
By: Rachel L. Grabenhofer
Posted: June 20, 2012
page 5 of 5
Microphasic micro-components and methods for controlling morphology via electrified jetting
US Patent 8187708
Publication date: May 29, 2012
Assignee: The Regents of The University of Michigan
The current disclosure provides methods for the preparation of multiphasic micro-components, such as core-shell or anisotropic (e.g., Janus) multiphasic particles with well-defined structures, using electrohydrodynamic co-jetting of two polymer solutions containing polyelectrolytes. Control of certain variables, such as relative conductivities of the two jetting solutions, manages the particle morphologies formed, leading to a predetermined phase orientation for the same polymer system. In certain aspects, after cross-linking, core-shell particles are stable in aqueous solutions and exhibit reproducible swelling behavior, while maintaining the original core-shell geometry.
In addition, micro-components formed in accordance with the present teachings are pH-responsive based on external environmental pH. Thus, such micro-components are useful for a variety of different applications, including micro- and nano-active ingredient delivery systems. In other aspects, multiphasic micro-components can be used in personal care compositions such as soaps, exfoliating scrubs, shampoos, lotions, sunscreens, self-tanning products, antiperspirant products, nail care products, cosmetics and the like.