Protecting the Genome of Skin Cells from Oxidative Stress and Photoaging

January 30, 2009 | Contact Author | By: L. Danoux, C. Jeanmaire, V. Bardey, G. Périé, M.D. Vazquez-Duchêne, V. Gillon, F. Henry, P. Moser and G. Pauly, Laboratories Serobiologiques, A Division of Cognis France
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Keywords: Photoaging | mitochondrial DNA | nuclear DNA | DNA damage | UVA | UVB | DNA repair | GADD45α | kaempferol sophoroside

Abstract: According to a concept proposed here, protection of nuclear DNA and mitochondrial DNA against UVB and UVA radiation can break the vicious cycle responsible for skin photoaging.

A new concept to fight the cycle responsible for photoaging has been proposed. It addresses ultraviolet (UVA and UVB) radiations of nuclear deoxyribonucleic acid (nuDNA) and mitochondrial DNA (mtDNA), and provides global protection by effects that are both preventive and curative. The concept is illustrated using a new phytochemical active aimed at preventing photoaging by protecting and repairing UV-induced DNA damage.

In human cells, the genome is represented by linear DNA in the nucleus, and also by circular DNA located in cell organelles named mitochondria. DNA constitutes an important cellular component because it is the carrier of genetic information that is read as a blueprint by which cells perform necessary operations in order to grow or survive.

The nucleus is the cell domain that harbors DNA, which constitutes the genetic material or genome. DNA is formed of chained nucleotide bases whose specifi c sequences, termed genes, carry the hereditary information. The nucleus conceals the initial steps of the central dogma of biology, which states that genes are transcribed into transportable messenger ribonucleic acid (mRNA) carrying the instructions up to cytoplasm where mRNAs are translated into determined proteins.  For the complete article, click on "Purchase this article."