Epidemiological studies indicating as association between diet and disease led to the investigation of a series of bioactive plant compounds. In Japan, for example, the incidences of cardiovascular disease, hormone-dependent cancers (breast, uterus and prostate) and menopausal symptoms (osteoporosis and hot flashes) are all substantially lower than in western countries. The traditional Japanese diet includes a significant amount of soy-based foods such as tofu and tempeh.
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