1,2-Alkanediols for Cosmetic Preservation

Oct 1, 2008 | Contact Author | By: Ravi Pillai, PhD; Gerhard Schmaus, PhD; Antje Pfeiffer; Sabine Lange and Aurélie Trunet, Symrise
Your message has been sent.
(click to close)
Contact the Author
Save
This item has been saved to your library.
View My Library
(click to close)
Save to My Library
Title: 1,2-Alkanediols for Cosmetic Preservation
1x 2-alkanediol; 1x 2-hexanediol; 1x 2-octanediol; multifunctional; preservationx
  • Article
  • Media
  • Keywords/Abstract

Keywords: 1 | 2-alkanediol; 1 | 2-hexanediol; 1 | 2-octanediol; multifunctional; preservation

Abstract: Straight chain 1,2-alkanediols are multifunctional ingredients with moisturizing and antimicrobial activities. Here, the authors examine the ability of these materials to boost the activity of preservatives and to provide broad-spectrum antimicrobial activity. In addition, the authors describe how to combine these compounds into formulations to optimize stability and efficacy.

Excerpt Only This is a shortened version or summary of the article you requested. To view the complete article, please log in or create an account. Registration is Free!

Straight chain 1,2-alkanediols have been used for more than 15 years as moisturizers with multifunctional activities.1–3 In fact, pentylene glycol, also known as 1,2-pentanediol, was the first of the 1,2-alkanediols introduced to the cosmetic industry in the early 1990s. Since then, 1,2-hexanediol (see Figure 1a); caprylyl glycol also known as 1,2-octanediol (see Figure 1b); and more recently, decylene glycol or 1,2-decanediol, also have become available in the personal care industry.

Short chain 1,2-alkanediols are amphiphilic compounds and thus, like 1,2-pentanediol and 1,2-hexanediol, are soluble both in water and cosmetic esters. On the other hand, 1,2-decanediol is a solid and soluble only in cosmetic esters. Apart from moisturizing and anti-microbial activities, some 1,2-alkanediols are used as solvents for various cosmetic actives and viscosity modifiers.

The present research reports the results of studies on the anti-microbial properties of straight chain 1,2-alkanediols, mixtures of them, and combinations of 1,2-alkanediols with other preservatives and antimicrobial compounds. Here, the authors evaluate the potential of 1,2-alkanediols for use as preservative boosters to reduce the levels of preservatives required in formulations. In addition, the authors discuss formulating with 1,2-alkanediols to optimize formulations for stability and efficacy.

Excerpt Only This is a shortened version or summary of the article you requested. To view the complete article, please log in or create an account. Registration is Free!

 

Close

Table 1. Combinations of materials tested

Table 1. Combinations of materials tested 

Table 2. MIC values

 Table 2. MIC values 

Table 3. MIC values

Table 3. MIC values 

Table 4. Viscosity measurements

Table 4. Viscosity measurements 

Figure 1: Chemical structures

Figure 1: Chemical structures  

Figure 2. Challenge test results

Figure 2. Challenge test results 

Figure 3. Challenge test results

 Figure 3. Challenge test results

Figure 4. Chemical structures

Figure 4. Chemical structures 

Figure 5. Challenge test results

Figure 5. Challenge test results 

Pillai: Alkanediols Footnotes

 a The Brookfield RVDV III Ultra rheometer is a device from Brookfield Engineering, Middleboro, Mass., USA.

b SymDiol 68 (INCI: 1,2-hexanediol (and) 1,2-octanediol) is a product and registered trademark of Symrise.
 

Formula 1. Nonfragranced anionic emulsion used

 Formula 1. Nonfragranced anionic emulsion used

Formula 2. Anionic o/w emulsion used

Formula 2. Anionic o/w emulsion used 

Next image >