Sytheon has dehydrated sorbitol to introduce a hydrating ingredient that is said to restore barrier homeostasis. Synovea DOI (INCI: Isosorbide Dicaprylate) is said to be naturally derived with a solid safety profile.
According to the company, water and barrier homeostasis of the epidermis is essential for the normal function of the skin and for normal stratum corneum (SC) hydration. It is a determinant of skin appearance, mechanical properties, barrier function and metabolism. In addition, it is indispensable in maintaining proper water balance of the body.
The hydrating ingredient is obtained from octanoic acid, which is found naturally in coconuts, palm oil breast milk and goat milk; and isosorbide, obtained by double dehydration of the biofeedstock sorbitol.
The ingredient reportedly has been clinically proven to improve skin hydration by up-regulating aquaporin 3 and having a synergistic effect with glycerol. In addition, it reportedly improves barrier homeostasis by up-regulating key genes/proteins associated with tight junction, desmosome and epidermal differentiation.