The Synergistic Antioxidate Effect of Ascorbyl 2-Phosphate and Alpha-Tocopheryl Acetate

May 6, 2003 | Contact Author | By: Axel Jentzsche and Harald Streicher, BASF AG; and Karin Engelhart, BioTeSys GmbH
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Keywords: antioxidants | vitamin C | vitamin E | tocopheryl acetate | sodium ascorbyl phosphate | photoaging

Abstract: The synergistic antioxidative effect of ascorbyl 2-phosphate and alpha-tocopheryl acetate was investigated in vitro using a human keratinocyte cell line and a fluorescence-based assay system.

The use of antioxidants in cosmetics has a long history. Two different modes of application can be distinguished. They are used either to stability the cosmetic formulation or to protect the skin.

As a formulation stabilizer, they serve as a "technical antioxidant." Here they are being used to prevent the oxidative deterioration of labile ingredietns such as unsaturated fatty acids or oxidation-prone active ingredeitns. Both synthetic compounds like butylated hydroxytoluene and natural antioxidants like alpha-tocopherol are frequently used for this purpose.