Encapsulating Hevea brasiliensis for Improved Antioxidant Penetration

Mar 19, 2014 | Contact Author | By: Thanaporn Amnuaikit, PhD, and Prapaporn Boonme, PhD; Prince of Songkla University, Songkla, Thailand
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Title: Encapsulating Hevea brasiliensis for Improved Antioxidant Penetration
antioxidant activityx Hevea brasiliensis extractx liposomesx DPPHx skin penetrationx
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Keywords: antioxidant activity | Hevea brasiliensis extract | liposomes | DPPH | skin penetration

Abstract: This article examines the ability of liposomes to improve the in vitro skin penetration of Hevea brasiliensis extract in a cream, for antioxidant benefits. Additionally, the sensory effects of the liposomes on the cream were assessed.

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T Amnuaikit and P Boonme, Encapsulating Hevea brasiliensis for improved antioxidant penetration, Cosm & Toil 129(3) 38 (Apr 2014)

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Developing products to address wrinkles and furrows is a challenge. In relation, several anti-aging theories have been proposed, among which, the free radical theory is prominent. This theory states that free radicals, having at least one unpaired electron, can deleteriously assault cell constituents and connective tissues, resulting in aging.1 Free radicals are generated upon exposure to many different stressors, including sun exposure, air pollution, cigarette smoking and alcohol consumption. Sickness and stress can also stimulate the production of free radicals in the body. Free radical production can be decreased by electron donation from antioxidants, in turn slowing the process of aging. The appearance of skin is reported to directly relate to its antioxidant content rather than actual age.2 In recent years, several plant extracts have been shown to exhibit antioxidant activity. In particular, serum extracted from latex of the Para rubber tree (Hevea brasiliensis), referred to here as Hevea brasiliensis or Hb extract, was reported for its thiol-containing antioxidants and other amino acids with antioxidant activity.3 These components made Hb extract an interesting cosmetic active candidate. Moreover, formulation development is important to the delivery of antioxidants to the skin.4 Lipid-based colloidal systems including lipid nanoparticles, liposomes and microemulsions are recognized for topical drug delivery,5 hence they can be adapted for cosmetics. Liposomes are colloidal vesicles composed of a phospholipid bilayer and encapsulating an internal aqueous phase. These biocompatible colloidal systems6 have been reported for many benefits in cosmetic formulations, such as enhancing the penetration of actives, increasing release duration and improving the stability of actives. Liposomes formulated with phosphatidylcholine from soybean, polysorbate 80a, and deoxycholic acid were previously reported for their effectiveness in delivering Hibiscus sabdariffa (roselle) calyx extract into pig skin.7 In consideration, the aim of the present study was to develop Hb extract liposomes, and compare the penetration of antioxidants from creams containing them (liposome cream) versus creams containing Hb extract in its original powder form (normal cream).

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Figure 1. EC50 for antioxidant activity

EC<sub>50</sub> for antioxidant activity

EC50 for antioxidant activity of Hb extract by DPPH method

Figure 2. Calibration curve

Figure 2. Calibration curve

Calibration curve between Hb extract concentrations and antioxidant activity intensities

Figure 3. Appearance of cream

Figure 3. Appearance of cream

Appearance of Hb extract liposome cream

Figure 4. Amount of extract collected

Figure 4. Amount of extract collected

Cumulative amount of Hb extract in receptor fluids from liposome and normal creams

Footnotes [Boonme, 129(3)]

Tween 80, Sigma-Aldrich
b Hb extract, PSU Innovation Trading Co., Ltd.
c Optima L-100XP Ultracentrifuge, Beckman Coulter Inc.
d Triton X100, The Dow Chemical Company
e Milli-Q water, Millipore Corp.
f Zetasizer, Malvern Instruments
g Tween 60 (INCI: Polysorbate-60) is a product of Croda, www.crodausa.com 
h Span 60, Sigma-Aldrich
j Carbopol Ultrez 21 (INCI: Acrylates/C10-30 Alkyl Acrylate Crosspolymer) is a product of Lubrizol Advanced Materials Inc./Noveon, www.lubrizol.com/personalcare.
k Whatman Paper No.1, Sigma-Aldrich

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