Patent Picks—Natural Preservatives, Beta-Lactam for Hair Growth, Allyl Caproate for Sensory and More

By: Rachel L. Grabenhofer

Posted: November 23, 2011

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In this patent, topical formulations are provided for the treatment or prevention of rosacea. The compounds included are α2 adrenoceptor agonists that act on the peripheral vasculature to cause vasoconstriction and thereby ameliorate the symptoms of rosacea. Intended for application via sprays, mists, aerosols, solutions, lotions, gels, creams, ointments, pastes, unguents, emulsions and suspensions, the compounds are delivered effectively in the skin of the patient but do not penetrate the skin in sufficient amounts to induce serious systemic side effects.

Compositions comprising quaternary ammonium compounds and organic carbonates
European Patent Application EP2387986
Publication date: Nov. 23, 2011
Assignee: Evonik Goldschmidt GmbH

Surprisingly, it has been found that compositions comprising quaternary ammonium compounds and at least one organic carbonate have low setting and melting points, good solubility and dispersability in aqueous media, a high flashpoint, are flakeable or pelletizable, and have a low VOC content. These compositions can be free from polyhydric alcohols, fatty alcohols and linear or branched alcohols having 8 to 36 carbon atoms and are nevertheless sufficiently hard and brittle at room temperature. These compositions are thus highly suitable for hair treatment formulations and other cosmetic, household or industrial applications utilizing quaternary ammonium compounds.

Process for producing o/w microemulsion preparation for external application
European Patent Application EP2387985
Publication date: Nov. 23, 2011
Assignee: Shiseido Co., Ltd.

According to this invention, the development of an o/w emulsion external preparation that is economical and easily produced without the need for a conventional cooling apparatus, as well as has long-term stability and smaller particle sizes, has been sought. The present invention thus provides a production method for a fine o/w emulsion external preparation having the emulsion particle size of 50 to 500 nm, and comprising the steps of mixing, at 70°C to 80°C: a) a hydrophilic nonionic surfactant, b) a linear higher alcohol having 16 or more carbon atoms, c) an oil component, d) an aqueous solvent, which can be soluble in water, wherein the critical micelle concentration of the hydrophilic nonionic surfactant in the aqueous solvent is higher than that in water; and e) water, in the amount of 5% to 25% of the total amount of a) to e), to prepare a w/o emulsion. Then, while mixing with stirring, adding f) water or an aqueous formulation at 10°C to 35°C into the w/o emulsion to invert it to a fine o/w emulsion. The production method needs no cooling apparatus, has excellent economical efficiency, can easily produce a fine o/w emulsion external preparation with excellent safety and stability.