Table 1. Summary of skin reactions in the described 200-person RIPT

In the 200-person RIPT, no clinically significant skin reactions were observed for PDO. High and low pH did not impact the skin results even at 75% PDO. A few subjects exposed to 25%, 50% and 75% PDO did exhibit barely perceivable or mild redness (erythema) at 24 hr or 72 hr post-challenge, but the sites were considered clinically insignificant at the final observation.