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Modeling UVB-induced Formation of Photoproducts in Human Keratinocytes

The authors describe a model to visualize the appearance of cyclobutane-pyrimidine dimers in the nuclei of normal human keratinocytes after UV irradiation. These dimers are one of the principal agents in DNA damage. The model can be used to assess the effect of a cosmetic ingredient on the formation of direct UV-induced lesions to DNA.

A Dermatological View—Squamometry: An Early Predictor of Changes in the Skin Barrier

Squamometry is useful in identifying the low or subclinical irritation potential of substances even before any change in the TEWL can be measured.

Testing Tactics: In Vitro Approaches to Antiaging Testing

Using proper methods, it is possible to screen materials for potential antiaging effects; in turn, these materials can be incorporated into cosmetic or personal care products. To properly screen antiaging materials, all that is required is a basic understanding of the aging process.

Testing Tactics--In Vitro Sensitization Models: Current Progress

Several interesting and promising approaches to in vitro skin sensitization testing are in development. Perhaps it will not be long before they are deemed valid and reliable alternatives to animal testing.

Measuring Reactive Oxygen Species in Skin with Fluorescence Microscopy

Several signs of skin aging have been attributed to the presence of free radicals. This paper discusses the application of two-photon fluorescence microscopy to determine the effects of sample formulations on the number of reactive oxygen species (ROS) formed in skin models.

Watermelon Survival Strategies for Skin DNA Protection

Plants living under extreme conditions have developed a strategy to protect their DNA and other important cell structures from environmental stress factors. In particular, watermelon (Citrullus lanatus) has adapted well to extreme conditions. Its survival strategy can be used in the field of skin care, as shown by several tests including a direct DNA protection assay, the COMET assay and 8-oxo-guanosine and p53 detection.

Tech Edge--Optical Tools to Examine the Structure of Cosmetics Products

To monitor or anticipate what can happen in the creation of a cosmetic product when components are combined and as time passes is no trivial task especially when compounded with the psychophysical needs for the product to fit a specific concept and to spread, feel, pour and appear elegant.

A Dermatological View: Antioxidant Inhibits UV Erythema In Vivo in Humans

Described here was an in vivo model to determine antioxidative capacity of a topical skin care emulsion versus the emulsion’s vehicle on human skin that was exposed to UVR. Results suggest the test emulsion and its vehicle control inhibited the induction of erythema and reduced inflammation caused by the UV exposure.

Testing Tactics: In Vitro Methods to Test Materials for UV Protective Capabilities

The methods described in this article highlight some of the markers that can be used to assess the UV protective effects of a test material. All of these markers represent either an index of UV-induced damage to the cell or the cell’s response to the damage.

A Dermatological View: Using Photochemiluminescence to Quantify the Antioxidative Capacity of Topicals

Exposure to ultraviolet radiation (UVR), air pollutants, chemical oxidants and aerobic microorganisms may damage the skin. In particular, reactive oxygen species (ROS) are considered a likely contributor to skin aging, cancer and certain skin disorders.

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A Dermatologic View—Bioengineering Analysis of Water Hydration

The water content of the stratum corneum (SC) influences almost every biophysical property measurable at the skin surface. Water hydration can be measured using the plastic occlusion stress test (POST) or the water sorption-desorption test (WSDT). These are detailed in the present article.

Using Texture Analysis to Substantiate Hair Care Claims

Texture analysis provides quantitative information about a material’s response when deformed by a controlled force. When texture analysis is applied to hair treated with various conditioners and styling fixatives, the results can help substantiate claims made about the effectiveness of these hair care products.

Evaluating Droplet Size in Nanoemulsions from a Novel Emulsifier System

This article describes two sophisticated techniques to measure the diameter of emulsion droplets on the nanometer scale and uses those techniques to test a new emulsifying agent capable of spontaneously creating emulsions with droplet sizes smaller than 300 nm.

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New Directions for Sensitive Skin Research

This brief review provides an insight into the current standing of sensitive skin research, including recent findings on the possible role of nerve growth factor as an underlying mechanism and predictive tool for sensitive skin.

Ciba Develops Test Method

Ciba Specialty Chemicals has submitted a master file to the US Food and Drug Association (FDA) for its new antimicrobial test method...

A Screening Technique for Antiperspirant Testing

A standardized in vivo test design for screening up to eight antiperspirant formulations in one panel is described. Dose-response curves for new raw materials or formulations can be performed in the same panel.