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Section: Testing > Animal Alternatives

Compass—Best Foot Forward

From an insider’s view, safety testing is an assumed step in the development of any product on the market. This puts the pressure on analytical and quality control efforts behind the scenes to ensure that ingredients and products meet or exceed expectations. In doing so, theoretically, no one else has to give it a second thought. For those who must give it considerable thought, this edition features two articles on testing, among other topics.

Comparing Methods to Measure Porcine Skin Integrity In Vitro

To confirm the integrity of porcine ski prior to penetration tests, published studies show that measuring transepidermal water loss, transdermal electrical resistance or caffeine penetration levels are often chosen techniques. New results demonstrate that

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ECHA on Combining Animal Alternative Data to Assess Sensitization

The ECHA recently published guidance for REACH registrants on reliably combining different sources of animal alternative-derived test data to assess the skin sensitizing potential of chemicals.

Nearly 900 companies have announced support of The Humane Cosmetics Act.

900 Companies Support Humane Cosmetics Act to End Animal Testing

The Humane Cosmetics Act, which would end animal testing for cosmetic products and ingredients in the U.S. and prohibit the import of cosmetics tested on animals around the world, has garnered support from nearly 900 companies.

Appointment of Commissioner Borg May Jeopardize Animal-alternative Test Progress

Cosmetics Europe recently urged the industry to oppose the appointment of Tonio Borg as Health Commissioner, as his "commitment to conclude the introduction of the March 2013 [animal testing] ban without addressing scientific reality or consumer needs is a great concern."

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3D Skin Substrate Meets Speed, Complexity and ECM-based Research Needs

Researchers from the University School of Dental Medicine in Boston have published on a 3D skin equivalent model with high throughput potential and greater cellular complexity originating from human ECM.

'Canada's legislation is expected to pass soon and, when it does, the United States will be the only country in North America without a national ban on animal testing for cosmetics.'

Canada Commits to End Animal Tox Testing While MoCRA Misses the Mark

Bill S-5 in Canada has passed with royal assent to end animal testing for chemical toxicity; cosmetics are expected to be next. Meanwhile, MoCRA in the U.S. missed the chance to address this major industry issue, one source critiques.

Public Comments Requested for Development of NICEATM-ICCVAM 2013-2017 Five-Year Plan

NIEHS and NICEATM invite public comments that can be considered by the ICCVAM and the agencies' program offices in updating the NICEATM-ICCVAM 2008-2012 Five-Year Plan to develop the 2013-2017 Five-Year Plan.

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Global Experts Outline Next-gen, Animal-alternative Cosmetic Test Tenets

With animal testing for the safety assessment of cosmetic ingredients and products banned in the EU, new methods are required to ensure human safety. As such, an international working group has compiled nine guiding principles to lead the development of new test methods.

Givaudan has also pledged to contribute to real-world case studies in animal-free safety assessment.

Givaudan Joins Animal-Free Safety Assessment Collaboration

Givaudan has also pledged to contribute to real-world case studies in animal-free safety assessment.

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BASF, Givaudan and IIVS Team Up for Animal Testing Alternative

The improved skin sensitization reactivity method will address the needs of toxicologists and regulators, predicting the potency of a sensitizer without the need for animal testing.

BASF and Givaudan collaborated to develop and validate alternative animal testing methods, leading to the first toxicology testing strategy without animals that was adopted by OECD.

BASF and Givaudan Develop First OECD-Approved Animal Test Alternatives

The OECD has, for the first time, approved a non-animal strategy to assess skin sensitization based on three tests. In addition, the Kinetic Direct Peptide Reactivity Assay was approved to predict the intensity of reactions. All tests are the results of BASF/Givaudan joint efforts.

ICCVAM Recommends Non-animal Endocrine Disruptor Screening

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has recommended a non-animal test method to identify estrogen agonist and antagonist activity. In addition to recommending the test, ICCVAM also found the method to provide a number of benefits over the method currently employed in the United States.

ICCVAM Recommends Ocular Safety Tests for Cosmetics and Other Products

Four test method evaluation reports are now available from ICCVAM that provide recommendations for performing eye safety testing more humanely, and for developing and using non-animal test methods and strategies. Among these reports, ICVAAM has recommended that a cytosensor microphysiometer (CM) test method may be used to screen surfactant-containing formulations such as personal care products for the ability to cause permanent or severe eye injuries.

France is the first country in the EU to export its “ordinary” cosmetics to China without testing on animals.

'Ordinary' French Cosmetics Become the First to Bypass China’s Animal Testing Mandate

France has become the first country in the EU to export “ordinary” cosmetics to China without testing on animals.

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