Characterizing the Anti-aging Effects of Hesperomeles heterophylla Hook Leaf Extract

A combination of factors affects skin functionality and appearance. Internal factors modulate the expression of key genes involved in skin homeostasis. Such intrinsic aging is genetically regulated and follows a chronological clock inside of cells, whereas environmental factors are responsible for actinic aging. Together, these factors target important metabolic pathways in skin cells that trigger the signs of aging, such as skin roughness and loss of biomechanical properties. At the molecular level, collagen synthesis is reduced in aging skin cells and cells damaged by UV radiation.¹ The expression of collagen-degrading matrix metalloproteinases (MMPs) is upregulated in aged cells and cells exposed to UV, infrared radiation or excessive heat.^{2, 3} Also, reactive oxygen species are implicated in the deleterious effects of aging.^{1, 4} In an effort to develop a natural active to address these skin aging issues, the efficacy of Hesperomeles heterophylla leaf extract was studied as a novel natural source for anti-aging actives that provide multiple skin benefits, as described in this paper.