Natural Preservative: SUPRAPEIN® [sample request]


Preservatives and antimicrobial agents are important to control and inhibit the growth of microorganisms in topical products. Most of the commonly used preservatives and microbial agents are synthetic. Alternatives include plant materials, which are a significant source of active constituents with a high level of antimicrobial activity.

Recognizing this demand and trend, Bio-Botanica Inc. developed a natural preservative, utilizing a proprietary combination of certain botanical extracts. Plants were used to develop this natural preservative, Suprapein®. 

This novel approach was unique enough to have “US Patent # 7214392 B2 issued by the US Patent” office covering the “Process and composition for inhibiting the growth of microorganisms.” 

 Suprapein has proven to be a well-balanced synergistic combination of botanical fractions possessing potent antimicrobial activity with MIC’s as low as 0.45% against a broad-spectrum of organisms including possible pathogenic organisms that may be introduced into products. These organisms include Gram-positive staphylococcus aureus; Gram-negative Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae and Pseudomonas aeruginosa; acid-fast bacterium, Mycobacterium smegmatis; the yeast, Candida albicans; and the filamentous mold, Aspergillus niger.


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