Dihydroavenanthramide D for Anti-irritant and Anti-itch

Nov 2, 2007 | Contact Author | By: Gerhard Schmaus, Martina Herrmann, Holger Joppe, Sabine Lange and Oskar Koch, Ravi Pillai, Joachim Röding, Symrise
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Title: Dihydroavenanthramide D for Anti-irritant and Anti-itch
avenanthramidex oatx dihydroavenanthramide Dx anti-irritantx anti-itchx
  • Article

Avenanthramides (anthranilic acid amides), a class of compounds found in oat at very low concentrations, have been reported to have antihistaminic activity. Indeed, the current authors have previously demonstrated the anti-itch and anti-redness efficacy of three naturally occurring avenanthramides: avenanthramides A, B and C. Now the authors report on the development and efficacy of four synthesized avenanthramides: avenanthramides D and E and dihydroavenanthramides D and E.

These various avenanthramides differ in the substituents on the cinnamic acid and anthranilic acid rings. Avenanthramides A, B and C are also known as avenanthramide Bp, Bf and Bc, respectively, where p, f and c are appendices for the individual cinnamic acid moieties; p means para-coumaric acid, f means ferulic acid, and c means caffeic acid. Avenanthramides D and E have the same substitution pattern in the cinnamic acid moiety as A and B and only differ in the anthranilic acid part.

Excerpt Only This is a shortened version or summary of the article that appeared in the November 2007 issue of Cosmetics & Toiletries magazine. If you would like a copy of the complete article, please contact us at customerservice@cosmeticsandtoiletries.com.