Recent in In vitro (page 9 of 11)

Testing Tactics--In Vitro Sensitization Models: Current Progress

Several interesting and promising approaches to in vitro skin sensitization testing are in development. Perhaps it will not be long before they are deemed valid and reliable alternatives to animal testing.

A Dermatological View: Antioxidant Inhibits UV Erythema In Vivo in Humans

Described here was an in vivo model to determine antioxidative capacity of a topical skin care emulsion versus the emulsion’s vehicle on human skin that was exposed to UVR. Results suggest the test emulsion and its vehicle control inhibited the induction of erythema and reduced inflammation caused by the UV exposure.

Testing Tactics: In Vitro Methods to Test Materials for UV Protective Capabilities

The methods described in this article highlight some of the markers that can be used to assess the UV protective effects of a test material. All of these markers represent either an index of UV-induced damage to the cell or the cell’s response to the damage.

Expanded Parameters for Particle Analysis

Fluid Imaging Technologies has launched a particle analysis instrument that permits 23 measurement parameters.

Evaluating Droplet Size in Nanoemulsions from a Novel Emulsifier System

This article describes two sophisticated techniques to measure the diameter of emulsion droplets on the nanometer scale and uses those techniques to test a new emulsifying agent capable of spontaneously creating emulsions with droplet sizes smaller than 300 nm.

Ciba Develops Test Method

Ciba Specialty Chemicals has submitted a master file to the US Food and Drug Association (FDA) for its new antimicrobial test method...

Using Texture Analysis to Substantiate Hair Care Claims

Texture analysis provides quantitative information about a material’s response when deformed by a controlled force. When texture analysis is applied to hair treated with various conditioners and styling fixatives, the results can help substantiate claims made about the effectiveness of these hair care products.

A Screen for Microbial Contamination

Celsis International introduces the next generation in bioluminescence technology that screens for microbial contamination of personal care products.

BioScreen Offers Asian Panels

Beginning fall 2006, BioScreen will begin offering Asian subject panels.

AMS Revolutionizes Absorption and Metabolism Studies

Quantification of percutaneous penetration and metabolism of skin care ingredients has seemed daunting; however, new technology provides a ready solution for the problematic arena. Accelerator mass spectrometry (AMS) is a new analytical method that measures a biological response better than the existing technique.

A Dermatological View: Using Photochemiluminescence to Quantify the Antioxidative Capacity of Topicals

Exposure to ultraviolet radiation (UVR), air pollutants, chemical oxidants and aerobic microorganisms may damage the skin. In particular, reactive oxygen species (ROS) are considered a likely contributor to skin aging, cancer and certain skin disorders.

Evaluating Antipruritics

Pruritus or itching is an unpleasant sensation that provokes a desire to scratch. Many factors such as chemical, mechanical, thermal and electrical stimuli can elicit the itch sensation. Mediators of itch presumably directly act on nerve fibers or lead to a nerve stimulation cascade whose final common pathway is interpreted in the central nervous system as itching. Putative receptors for itching are C-fibers with exceptionally low conduction velocities and insensitivity to mechanical stimuli. Histamine, the proto-typical chemical mediator of itch, which is released during mast cell degranulation and mediates its effects in the skin via H1 receptor, is the best-known experimental pruritogen.

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