Preservative efficacy testing or "challenge testing" is performed on aqueous cosmetic and drug products to determine the minimum effective concentration of antimicrobial preservatives required for adequate preservation. Products are satisfactorily preserved if they meet appropriate acceptance criteria. Methods of preservative efficacy testing include: compendial methods, such as the United States Pharmacopoeia (USP) and the European PHarmacopoeia (EP) methods; trade association methods, such as the Cosmetic, Toiletry & Fragrance Association (CTFA) method; and rapid procedures, such as the linear regression method.1-4
Preservative Efficacy Testing of Aqueous Cosmetics and Drugs without Counting Colonies
May 6, 2003 | Contact Author | By: D.S. Orth and K.S. Delgadillo Eck, Neutrogena Corp.
Abstract: A miniaturized system using broth enrichment followed by either streaking on agar or fluorescence treatments can eliminate colony counting in the linear regression method of preservative efficacy testing.
Z-COTE LSA provides broad-spectrum protection from long wave UVA rays and medium wave UVB rays by physically scattering, reflecting and absorbing solar radiation.
- Zinc Oxide
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