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ICCVAM Recommends Ocular Safety Tests for Cosmetics and Other Products
Posted: September 22, 2010
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In the third report, ICCVAM presents recommendations on use of an in vitro ocular safety testing strategy proposed for characterizing eye injury hazards for products used as antimicrobials regulated by the US Environmental Protection (EPA). While some of the methods appear promising, ICCVAM concluded that there are currently insufficient data with which to adequately demonstrate that the proposed strategy can accurately classify test substances to the appropriate EPA ocular hazard category, and recommended that further studies are needed.
In the fourth report, ICCVAM recommends that a proposed low volume rabbit eye test (LVET) should not be used for future regulatory testing due to poor predictivity when compared to the current standard rabbit eye test. However, ICCVAM concluded that data from past studies that used the LVET could be considered in a weight-of-evidence approach to classify ocular hazards.
ICCVAM carried out the technical evaluation of the proposed methods and strategies in conjunction with the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). The ICCVAM test method evaluation reports include the ICCVAM recommendations, ICCVAM-recommended protocols, final background review documents, independent peer review panel report, and the data used for the ICCVAM evaluations.
The reports and recommendations have been transmitted to Federal agencies for their review and response to ICCVAM in accordance with the provisions of the ICCVAM Authorization Act of 2000, which requires agencies to review the recommendations and respond to ICCVAM within 180 days.