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Feb 28, 2006 | 06:06 PM CST
By: CM Lee, University of California; HI Maibach, …
The water content of the stratum corneum (SC) influences almost every biophysical property measurable at the skin surface. Water hydration can be measured using the plastic occlusion stress test (POST) or the water sorption-desorption test (WSDT).
Jan 13, 2006 | 12:31 PM CST
ISPE Laboratories presents a new method to evaluate the solar protection factor of water-resistant products.
Jan 02, 2006 | 01:04 PM CST
A Dermatological View: Using Photochemiluminescence to Quantify the Antioxidative Capacity of Topicals
By: H Zhai, MD, and HI Maibach, MD, University of …
Exposure to ultraviolet radiation (UVR), air pollutants, chemical oxidants and aerobic microorganisms may damage the skin. In particular, reactive oxygen species (ROS) are considered a likely contributor to skin aging, cancer and certain skin disorders.
Dec 23, 2005 | 05:59 PM CST
By: N.O. Wesley and Howard I. Maibach, MD
The economic burden of contact dermatitis is extensive due to work hours lost and physician visits. In the workplace, for example, contact dermatitis (irritant and allergic) accounts for 40% of all occupational illnesses (excluding injury) and 25% of time lost from work. Common sensitizers leading to allergic contact dermatitis (ACD) include metals, plants, cosmetics, rubber compounds and medicines.
Dec 23, 2005 | 05:53 PM CST
Correlation of Long-term Physical Stability of Emulsions with the Short-term Rheological Measurements
By: Tharwat Tadros, Jeremie Nestor, Marie Claire-T…
Three short-term rheological measurements on some model personal care emulsions showed good correlation with long-term physical instability of the emulsions. Use of these rheological measurements can shorten the time to test the stability of new formulations.
Dec 23, 2005 | 05:38 PM CST
By: A. zur Muehlen, A. Klotz, M. Veeger, B. Thorne…
This study utilizes a 3D skin model to investigate barrier repair after damage with SDS and application of a skin care emulsion; it also demonstrates the suitability of using 3D skin models to study barrier repair.
Dec 23, 2005 | 05:31 PM CST
By: Hongbo Zhai, MD, and Howard I. Maibach, MD, Un…
Pruritus or itching is an unpleasant sensation that provokes a desire to scratch. Many factors such as chemical, mechanical, thermal and electrical stimuli can elicit the itch sensation. Mediators of itch presumably directly act on nerve fibers or lead to a nerve stimulation cascade whose final common pathway is interpreted in the central nervous system as itching. Putative receptors for itching are C-fibers with exceptionally low conduction velocities and insensitivity to mechanical stimuli. Histamine, the proto-typical chemical mediator of itch, which is released during mast cell degranulation and mediates its effects in the skin via H1 receptor, is the best-known experimental pruritogen.
Dec 23, 2005 | 04:31 PM CST
By: Alicia Roso and Riva Brinet, SEPPIC
SEPPIC has developed rheology and texture analysis protocols that, when used in combination, provide useful data regarding the impact of raw material choice on all the development steps: manufacturing procedure, formulation stability, skin feeling.
Dec 23, 2005 | 04:09 PM CST
By: Tatiana Maria de Almeida Silva, Ketylin Fernan…
The authors determined the quality of a photoprotector W/O cream by evaluating its microbial control, physicalchemical stability and sensory appeal in comparison to an O/W photo-protector cream.
Dec 23, 2005 | 03:31 PM CST
By: M. Ines R. M. Santoro, D.A.G.C. Oliveira, E.R.…
The authors have validated a high performance liquid chromatographic (HPLC) method for the quantitative determination of benzophenone- 3 and octyl methoxycinnamate present in sunscreen emulsions.