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Recent in Testing (page 23 of 27)

Designing Mild Personal Care Products: A Case Study

This article reviews the mechanisms underlying skin irritation and sensitization, and methods used in a case study to test cosmetic products for their potential to cause irritation. It also covers the main skin conditions that can influence susceptibility to irritation, as well as ingredients affecting the mildness of cosmetic products.

Inducing Hormesis for a Lipofilling-like Action

The present article discusses a new approach to mimic lipofilling—the activation of hormesis, which is accomplished by the described encapsulated active designed to induce a transitory stress and initiate an overcompensation to reestablish homeostasis. This leads to the compensation of age-induced lipoatrophy and correction of wrinkles and folds, for a younger-looking appearance.

Clinical Evaluation of a Zinc- and Copper-based Eye Area Anti-aging Complex

A zinc and copper complex generating biomimetic electricity on a physiological level is shown here to improve the signs of photoaging in preclinical and clinical studies. This complex was applied to the eye area to confirm its efficacy as an anti-aging treatment option with good skin tolerance.

Improved UV Testing to Prevent Product Degradation

Atlas Material Testing Technology has launched the fourth generation of its SUNTEST CPS+ with improved features such as improved quality of light, an easier viewed larger display panel, eight user languages and two pre-programmed test methods.

Detecting Estrogenic Endocrine Disruptors in Personal Care Products and Supplements

Endocrine disruptor chemicals (EDCs) are a class of chemicals that has raised alarm for being linked to a wide variety of detrimental effects on human and wildlife populations, e.g., cancers, precocious puberty and obesity. Thus, there is a need to test personal care products and supplements for EDCs, which can be accomplished using the validated bioassay described here.

Stability Testing

Cosmetic companies support and conduct stability study programs because it is good business. Any improvement in stablity of a product is important for product performance, consumer satisfaction and economics.

Wise Words From the Bench with Gavin Greenoak

After 25 years in the industry, Gavin Greenoak, managing and scientific director of the Australian Photobiology Testing Facility Pty., Ltd. (APTF), continues to strive for a better understanding of the interaction of light and the human body. Greenoak’s career began in cancer research, which has afforded him unique insight of skin biology and the effects of sun exposure.

Permeation Method Developed As Alternative to Franz Cell

Pion Inc. has introduced a test method that predicts the permeability of drugs and dermal formulations through the human skin without the cost and low throughput restrictions of the Franz cell chamber.

NICEATM Calls for Scientific Experts and Data on Eye Testing

The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) is looking for scientific experts and data for a scientific review panel.

Large-scale Screenings of Botanical Ingredients: Challenges and Opportunities

Botanical ingredients are interesting for their unique and complementary chemical diversities yet they are criticized for these very traits, which make quality assurance, reproducibility and good phytochemical characterization—required for successful high throughput screening, difficult. This article discusses these challenges as well as the benefits of large-scale screenings of botanical extracts that are currently used or developed for cosmetic product development.

A Synthetic Tissue-based In vitro Ocular Irritation Assay

The testing of personal care products for ocular irritancy ensures their safety, proper labeling and consumer satisfaction. In relation, there is a current demand for animal-alternative tests. Thus, described here is a method using synthetic tissue to test for mild, moderate and severe ocular irritation, including data validating this method as an effective means to screen products.

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