Ascorbic acid on collagen: Garcia-Mercier investigated the effect of a w/o emulsion containing ascorbic acid on collagen neosynthesis in human full thickness skin discs in culture.1 The response of human skin disks to agents having the ability to increase collagen synthesis was investigated. Seven experiments were performed, each using skin disks obtained from female patients. L-ascorbic acid in the culture medium was incubated with skin for 72 hours. Collagen synthesis was evaluated by measuring 3H-proline incorporation into dermis proteins. Expected effects were found and results were shown to be reproducible. Two cosmetic formulations – a clear solution and a w/o emulsion containing L-ascorbic acid – were then tested by topical application on the human skin disks and incubated for 72 hours.
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