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Coenzyme Q10 nanoparticles, preparation method thereof and composition containing said nanoparticles
European Patent Application EP2417970
Pulication Date: Feb. 15, 2012
Assignee: Korea Research Institute of Bioscience and Biotechnology
Provided are a coenzyme Q10 nanoparticle, a method of preparing the same and a composition having the nanoparticle. According to the present invention, coenzyme Q10 may be dissolved in only a water-miscible organic solvent, and easily made into a nano-sized particle and solubilized under a low energy condition, for example, by simple stirring. The coenzyme Q10 may be dispersion-stabilized by an amino acid or protein. The coenzyme Q10 is formed in a nano-sized particle and solubilized, an absorption rate may be increased and simultaneously deliver the amino acid and protein with the nanoparticle. Thus, the coenzyme Q10 nanoparticle can be effectively used in food, cosmetics and medicine.
Coenzyme Q10 is referred to as ubidecarenone, and is a ubiquinone present in higher animals, having 10 isoprene units on a 2,3-dimethoxy-5-methyl-6-polyprenyl-1,4-benzoquinone side chain. It is known that coenzyme Q10 acts not only as a coenzyme, but also as a vitamin-like material improving oxygen efficiency. In addition, it is reported that coenzyme Q10 is essential to produce adenosine triphosphate in mitochondria, and is reported to improve immunity and to have an effect on a heart disease, hyperpiesia, rheumatic valve disease, alveolitis, etc. Coenzyme Q10 contributes to prevention of congestive heart failure, cerebrovascular occlusion and side effects of anticancer drugs (prevention of cardiogenic dysfunction caused by adriamycin), as well as fatigue recovery, regeneration of energy, and antioxidation of active oxygen in a living organism. Further, it is expected to function as an external skin application, thereby showing an anti-aging effect.
Elastin protective polyphenolics and methods of using the same
US Patent 8114829
Publication Date: Feb. 14, 2012
Assignee: Human Matrix Sciences LLC and The Hospital for Sick Children
Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.