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Herbal Extracts and Sebum Control and Other Topics
By: Charles Fox, Independent Consultant
Posted: October 4, 2004, from the October 2004 issue of Cosmetics & Toiletries.
page 7 of 11Water (aqua)
Formulation and the topical delivery of alpha-tocopherol: Rangarajan et al. report on the effect of formulation on the topical delivery of alpha-tocopherol.11 The objective of this research was to investigate the effect of concentration and delivery system on skin permeation of alpha-tocopherol (alpha-T). Also, the addition of sunscreens and oleic acid on alpha-T permeation was studied using an in vitro micro-Yucatan pig skin model. Various delivery systems of alpha-T (1%) were formulated, which included simple solutions, gels, emulsions, and microemulsions. The experimental design chosen for this study was a statistical randomized complete block design. The results showed that alpha-T delivery was proportional to its concentration. The hydro-alcoholic gel delivered significantly higher amounts of alpha-T into the receptor than the other gels used. A microemulsion containing isopropyl myristate emerged as the best delivery system for alpha-T among all the systems studied.
Pig skin is a suitable in vitro model for studying the permeation of alpha-T and possibly other antioxidants, though in vivo experiments in humans are required to further corroborate the data.
Visible capsules in clear formulations: The Gillette Company in a recent patent discloses clear personal care compositions containing visible capsules.12 The composition of a clear antiperspirant gel composition is shown in Formula 7.
|Formula 7. Clear antiperspirant gel with colored particles12|
|Aluminum zirconium tetrachlorohydrex Gly||29.00%|
|Cyclopentasiloxane (and) PEG/PPG-18/18 dimethicone||9.52|
|Dimethicone (and) trisiloxane||6.09|
Dec 03, 2013 | 01:02 PM CST
Oct 30, 2013 | 11:50 AM CDT