Patent Picks—Gels for Anti-acne and Wrinkle-blurring, Oridonin for Slimming and More

Oct 27, 2010 | Contact Author | By: Rachel L. Grabenhofer
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Title: Patent Picks—Gels for Anti-acne and Wrinkle-blurring, Oridonin for Slimming and More
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Chosen biweekly by Rachel Grabenhofer, Cosmetics & Toiletries magazine editor, for their relevance to personal care, Patent Picks are taken from publicly available sources. This edition features recently issued patents relevant to anti-acne and other skin care compositions.

Mild, structured, multi-phase personal cleansing compositions comprising density modifiers
US Patent 7820609
Publication date: Oct. 26, 2010
Assignee: The Procter & Gamble Company (Cincinnati, OH, USA)

This patent discloses a mild, multi-phase cleansing composition that includes a cleansing phase including a structured surfactant component that has a first density, a benefit phase including an emulsion that has a second density and a density modifier; wherein the first density differs from the second density by less than 0.15 g/cm3. The structured surfactant component includes at least one surfactant and provides a total lather volume of at least 600 mL. The emulsion is either an oil in water or an oil in water emulsion.

Non-limiting examples of these optional ingredients include vitamins and derivatives thereof, e.g., ascorbic acid, vitamin E, tocopheryl acetate; sunscreens; thickening agents; preservatives for maintaining the antimicrobial integrity of the cleansing compositions; anti-acne medicaments; antioxidants; skin soothing and healing agents, i.e. aloe vera extract and/or allantoin, etc., and the like.

Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
US Patent 7820186
Publication date: Oct. 26, 2010
Assignee: Galderma Research and Development

Described here are dermatological/cosmetic gel compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne. The disclosed compositions comprise at least one retinoid, dispersed benzoyl peroxide, and at least one pH-independent gelling agent; all of which are formulated into a physiologically acceptable medium.

Oleaginous pharmaceutical and cosmetic foam
US Patent 7820145
Publication date: Oct. 26, 2010
Assignee: Foamix Ltd.

The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents and having unique therapeutic properties as well as methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a cosolvent, and mixtures thereof; wherein the solvent is present at approximately 70% to 96.5% w/w of the total composition, the nonionic surface-active agent at approximately 0.1% to < 10% w/w of the total composition; and at least one gelling agent at approximately 0.1% to 5% w/w of the total composition. In addition, a therapeutically effective amount of at least one active agent and at least one liquefied or compressed gas propellant at approximately 3% to 25% w/w of the total composition is included.

SOD/catalase mimetics for the treatment of skin damage
WO/2010/120875
Publication date: Oct. 21, 2010
Assignee: Eukarion Inc. and Bernard Malfroy-Camine

Diclosed in this patent are methods and an apparatus for diagnosing and treating oxidative skin damage in a subject. The therapeutic method can comprise: a) diagnosing a level of oxidative skin damage in the stratum corneum of a subject; and b) recommending a therapeutic regimen for the treatment of oxidative skin damage in a subject, wherein said recommendation comprises a pharmaceutical formulation including one or more specific synthetic SOD/catalase mimetics sufficient to treat the level of damage diagnosed. The diagnostic method can further include obtaining a sample from the stratum corneum of a subject; measuring the level of at least one oxidized substance in the sample; and comparing a detected level of the oxidized substance with a standard, whereby an elevated level of the oxidized substance is indicative of skin damage.

Oridonin for use in slimming, antiaging and other cosmetic compositions
WO/2010/119423
Publication date: Oct. 21, 2010
Assignee: Sederma, Arnaud Fournial and Philippe Mondon

The present invention relates to cosmetic compositions comprising oridonin and new cosmetic uses. Oridonin is described for fighting the signs of cutaneous aging and for slimming. A composition comprising a combination of oridonin and darutigenol or a derivative thereof, in particular darutoside, is disclosed together with the cosmetic use of such composition.

Use of oxime derivative of 3,5-seco-4-nor-cholestane as an antioxidant
US Patent Application 20100267837
Publication date: Oct. 21., 2010
Assignee: Trophos

The invention relates to the use of at least one oxime derivative of 3,5-seco-4-norcholestane as antioxidants in the cosmetics and food fields, and as antioxidant preservatives that can be used, in particular, in cosmetic, food and pharmaceutical products. According to the invention, it is possible to combine the oxime derivative of 3,5-seco-4-nor-cholestane or of one of its derivatives with other active ingredients for the prevention and/or treatment of cutaneous diseases. Such active ingredients may include: antiseborrhoeics such as progesterone; antidandruff agents such as octopirox or zinc pyrithione; and anti-acne agents such as retinoic acid or benzoyl peroxide, among others.

Topical compositions containing desthiobiotin and its derivatives and a method to treat skin
US Patent Application 20100267792
Publication date: Oct. 21, 2010
Assignee: Avon Products, Inc.

This patent describes topical compositions and methods of use to treat symptoms of reduced skin elasticity; said compositions comprise desthiobiotin and certain desthiobiotin analogues. These compounds are said to be effective in stimulating LOXL-1 activity and can thus increase elastin, remodeling and improving the appearance of fine lines, wrinkles, skin sagging and other symptoms of reduced elastin function.

Flux-enabling compositions and methods for dermal delivery of drugs
US Patent Application 20100267678
Publication date: Oct. 21, 2010
Assignee: ZARS Pharma, Inc.

The present invention describes adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle and a solidifying agent, where the solvent can include a volatile solvent system comprising at least one volatile and one non-volatile solvent, wherein the non-volatile solvent is a flux-enabling non-volatile solvent capable of facilitating the delivery of the drug over a sustained period of time. The formulation can have a viscosity suitable for application to a skin prior to the evaporation of the volatile solvents system.

Gel technology to blur fine lines, wrinkles
US Patent Application 20100266649
Publication date: Oct. 21, 2010
Assignee: Avon Products, Inc.

This patent discloses a gel system comprising a fractal network of nanoparticles and macroscopic particles. The gel system is capable of forming an optical gel that is said to effectively blur fine lines and wrinkles as a consequence of the size domain differences between the fractal particles and the macroscopic particles. Cosmetic compositions comprising such gels and methods for their use are also disclosed.

Cosmetic compositions for imparting superhydrophobic films
US Patent Application 20100266648
Publication date: Oct. 21, 2010
Assignee: Avon Products, Inc.

In this patent, compositions and methods are disclosed for imparting super-hydrophobic properties to cosmetics, which can be used to significantly improve water repellency, compared with traditional cosmetics. The compositions include a hydrophobic film former and hydrophobic particles in an emulsion base.

Two-coat cosmetic compositions
US Patent Application 20100266517
Publication date: Oct. 21, 2010
Assignee: Avon Products, Inc.

Two-coat compositions and methods are disclosed that form cosmetic films on a biological surface that are long-lasting, transfer-resistant, water-proof, oil-proof, non-migrating, comfortable to wear, and that are capable of filling in fine lines and wrinkles. The two-coat compositions generally comprise a hydrophilic base coat composition and a top coat composition, and are useful for formulating cosmetics and personal care products.

Pharmaceutical foam
US Patent Application 20100266511
Publication date: Oct. 21, 2010
Assignee: Stiefel Research Australia Pty Ltd.

The present invention provides for various pharmaceutically active topical delivery compositions. In particular, compositions described by this patent are present in a pressurized container comprising a quick-breaking alcoholic foaming agent, such that when the composition is released, i.e. dispensed, from the pressurized container, a quick-breaking temperature sensitive foam is formed. In addition, the present invention provides various aspects related to such compositions, including methods for modulating a foam characteristic; methods for improving the shelf-life of a pharmaceutically active compound; methods for the percutaneous treatment of various diseases, infections and illnesses; and methods for evaluating foam characteristics.