Ethyl Lauroyl Arginate HCl for Natural Preservation

December 2, 2011 | Contact Author | By: Maria Minguet, PhD; Rut Barcelona, MD; Eduard Casas, PhD; Maite Beltrán, PhD; and Joan Seguer, PhD, Vedeqsa (Grupo LAMIRSA)
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Keywords: amino acid | antimicrobial | eco-friendly | anti-dandruff | dermo-purifying | preservative

Abstract: Ethyl lauroyl arginate HCl (LAE), derived from natural lauric acid and L-arginine, is shown here to provide broad-spectrum activity against microorganisms including Malassezia furfur and Propionibacterium acnes. In vitro tests corroborated by in vivo evaluations suggest its efficacy in anti-dandruff and dermo-purifying applications.

In recent years, several preservatives either have been banned or their use strongly limited, which is the case for formaldehyde, its releasers and isothiazolinones.1 In addition, some studies have misleadingly related parabens with a higher risk of cancer;2 so although parabens are the most commonly used preservatives in skin care due to their low sensitizing potential and good efficacy, with continued scrutiny from the market, many manufacturers are omitting them and promoting their cosmetics as “paraben-free.”

Currently, the ideal antimicrobial must show high antibacterial activity yet remain safe for human use and for the environment—and if possible, be based on naturally occurring substances. Considering these desired properties, the present paper explores ethyl lauroyl arginate HCl (LAE) for antimicrobial activity particularly against the microorganisms Malassezia furfur, involved in the proliferation of dandruff, and Propionibacterium acnes, involved in acne formation.