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The use of protective enzymes in cosmetics has been resisted because of their well-known instability. However, we report here on heat- and UV-stable enzymes obtained from hydrothermal vents deep in the ocean. In vitro and cell culture studies were carried out to test the potential for cosmetic applications. Catalase-like, SOD-like and glutathione peroxydase-like activities, all heat activated, were found to protect human skin fibroblasts, cell membrane lipids and collagen contraction capacity.
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