Researcher Develops Probe for Non-invasive Below Skin Imaging

Jannick Rolland, PhD, an optics professor at the University of Rochester in New York, has developed an optical probe equipped with a liquid lens that takes images under the skin’s surface without the use of invasive procedures.

Predicting the Percutaneous Penetration of Cosmetic Ingredients

By: Sara Farahmand, PhD, University of Cincinnati …

While previous algorithms for predicting the skin absorption of permeants was based on in vitro data, the present article proposes a quantitative structure-activity relationship (QSAR) model based on in vivo human data. Here, a set of human in vivo data is described that provides entry into predicting the penetration of cosmetic ingredients.

Is Cosmetic Science Really "Bad"? Part IV: How Scientific is Cosmetic Science?

By: Johann W. Wiechers, PhD, JW Solutions

Six questions from Michael Shermer’s Baloney Detection Kit have been discussed in this series. The results were not flattering for cosmetic science (read: cosmetic scientists) but cosmetic science did not score badly on all points. Questions seven and eight, described here, discriminate true science from borderland science and non-science or nonsense.

Mechanisms of Tape Stripping and Protein Quantification

By: Ali Alikhan, MD, and Howard I. Maibach, MD

In this article, several methods to quantify the protein collected by tape stripping are described, including traditional gravimetric methods as well as novel colorimetric and visible spectroscopic techniques. Further, one colorimetric method is described to effectively determine the keratolytic efficacy of various materials in vivo, suggesting additional roles for this method.

Testing in Cosmetic Valley

By: Elian Lati, Pascal Svinareff, Marc Feuilloley …

Raman spectroscopy and fringe projection are a few of the methods that have revolutionized the objectification market.

In the Land of the Blind: Applying a Single-blind Study to Finished Products

By: Johann W. Wiechers, PhD, JW Solutions

Following positive feedback from a previous column on the placebo effect, Wiechers readdresses clinical study design in relation to cosmetic claim substantiation—this time discussing when to perform double-blind studies and when to perform single-blind studies.