Comparing Methods to Measure Porcine Skin Integrity In Vitro

Comparing Methods to Measure Porcine Skin Integrity In Vitro

May 6, 2003 | By: S. Richert, A. Schrader and K. Schrader, Institut Dr. Schrader Creachem GmbH
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Title: Comparing Methods to Measure Porcine Skin Integrity In Vitro
in vitro testingx skin penetrationx skin integrityx porcine skin modelx
  • Article

Initial evaluation of the in vitro porcine skin model has demonstrated its feasibility and consequently led to the OECD guideline TG428. Fresh porcine skin, which has been reduced to horny layer and epidermis plus some dermal tissue, is often used to determine the percutanous absorption of test substances in different vehicles. Punched circular pieces of porcine skin are placed in suitable diffusion chambers for testing.