DDS Liposomes for Cosmetic Delivery and Other Recent Literature Findings

Jul 1, 2009 | Contact Author | By: Charles Fox, Independent Consultant
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Title: DDS Liposomes for Cosmetic Delivery and Other Recent Literature Findings
patentsx DDS liposomesx
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Keywords: patents | DDS liposomes

Abstract: In this month’s survey of recent patent and literature research, the author describes money-making ideas in the personal care industry, ranging from regulating sebum with spheroids to transparent film UV protection, copolymer water repellents and an aqueous amino acid preservative.

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In this month’s survey of recent patent and literature research, the author describes money-making ideas in the personal care industry, ranging from regulating sebum with spheroids to transparent film UV protection, copolymer water repellents and an aqueous amino acid preservative.

Skin and Skin Care 
Peptides for antiaging: The Research Foundation of the State University of New York disclosed peptides of fibronectin and vitronectin and variants thereof that have certain cosmetic activities, including growth factor-binding.1 Also described are fragments of growth factors that bind to fibronectin and inhibit binding of full-length growth factors to the same. Compositions containing such fragments are useful in wound care, cancer treatment and cosmetic treatments for wrinkles or UV photodamage of skin. These fragments allow the growth factor to retain biological activity and can be used to complement the loss of fibronectin or vitronectin from cells. The identification of minimal domains of fibronectins to promote the survival of fibronectin-null cells is demonstrated.

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Footnotes

aMerquat Plus 3330 (INCI: Polyquaternium-39) is a product of Nalco.

bSKICON-200 is a device manufactured by I.B.S. Co., Ltd.

cVAPO-SCAN is a device manufactured by Asahi Biomed.

Formula 1. Sebum flow regulator2

A.
Lauric acid  11.50%w/w
Oleic acid 11.50
Isostearic acid 5.75
Tricaprin 11.50
Triolein 11.50
Glyceryl isostearates 5.75
Oleyl oleate 10.40
Myristyl myristate 10.40
Isostearyl isostearate 5.20
Squalene 12.00
Cholesterol oleate 3.00
Cholesterol 1.50
B.
Artificial sebum mixture in A 40.00
Polyethylene (CL-2080, Kobo Products) 60.00

Formula 2. Microemulsion shampoo3

Microemulsion Composition
Decyl glucoside (Plantacare 2000 UP, Cognis) 17.50%w/w
Glyceryl oleate (Monomuls 90-O 18, Cognis) 8.00
Dicaprylyl ether (Cetiol OE, Cognis) 20.00
Water (aqua) qs to 100.00
Shampoo Composition
Sodium laureth sulfate (Texapon N 70, Cognis) 9.00
Cocamidopropyl betaine (Dehyton PK 45, Cognis) 3.00
Microemulsion (above) 1.78
Polyquaternium-10 (Dekaquat 400 KC, Dekker) 0.20
PEG/PPG-120/10 trimethylolpropane trioleate (Arlypon TT, Cognis) 0.65
Methyldibromo glutaronitile (and) phenoxyethanol (Euxyl K 400, schülke inc.) 0.10
Water (aqua) qs to 100.00

Formula 3. Permanant wave composition5

Ammonium thioglycolate 21.30%w/w
Ammonium bicarbonate 5.00
Butylene glycol 3.00
Polyquaternium-16 0.50
PEG-40 hydrogenated castor oil 0.70
Fragrance (parfum) 0.40
Ammonia, 25% qs to pH 8.3
Water (aqua) qs to 100.00

  

Formula 4. Sunscreen with zinc oxide6

Zinc oxide microparticles 20.00%w/w
Lauryl PEG-9 polydimethylsiloxyethyldimethicone (KF 6038, Shin-Etsu) 5.00
Decamethylcyclopentasiloxane 25.00
Dimethylpolysiloxane 5.00
2-Ethylhexyl-p-methoxycinnamate 10.00
Dimethylsilanediol-hexylmethylsilanediol copolymer 5.00
PEG-9 dimethicone 1.00
Butylene glycol 5.00
Ethanol 3.00
Sodium chloride 0.50
Preservative qs
Water (aqua) qs to 100.00

  

Formula 5. Water repellant sunscreen7

Glyceryl stearate citrate 0.50%w/w
Cetearyl alcohol 2.00
Styrene/acrylate copolymer 5.00
Vinylpyrrolidone/acrylic acid copolymer 0.50
Butylene glycol dicaprylate/dicaprate 10.00
Octyldodecanol 3.00
Myristyl myristate 1.00
Glycerin 2.00
Butylmethoxydibenzoyl methane 2.50
Octyl salicylate 4.00
Phenylbenzimidazole sulfonic acid 3.00
Sodium starch octenyl succinate 3.00
Alcohol 0.50
Taurine 0.10
Folic acid 0.01
Vitamin E acetate 0.20
Disodium EDTA 0.10
Fragrance (parfum) qs
Preservative qs
Dyes qs
Sodium hydroxide qs
Water (aqua) qs to 100.00

Formula 6. Three-step nail color8

Color precursor
Film formers 14.00%w/w
Plasticizers 5.00
Volatile solvent 79.00
3,3-bis(2-Methyl-1-octyl-1H-indol-3-yl)phthalide (color precursor) 0.50
Aminomethylpropanol 0.40
Pigments/fillers 1.00
Gelling agent 0.10
Color activator
Isopropyl alcohol 96.00
Citric acid 4.00
Color deactivator
Isopropyl alcohol 95.00
Aminomethyl propanol 5.00

Formula 7. Foundation lotion11

PEG-30 dipolyhydroxystearate (Arlacel P135, Croda) 5.00% w/w
C12-13 dimalate 8.00
Capric (and) caprylic acid glycerides 1.00
Modified hectorite 0.80
Propylene carbonate 0.50
Pigments coated with amino acids 10.00
Isododecane 15.00
Polymethylmethacrylate 5.00
Sodium chloride 0.70
Glycerol 2.50
Butylene glycol 3.50
Ethyl alcohol 10.00
Propylene glycol 1.00
Glycerol 2-ethylhexylether 1.00
Octane-1,2-diol 1.00
Water (aqua) qs to 100.00

 

Formula 9. Stable, low pH, low viscosity o/w emulsion14

Polysorbate 60 0.80% w/w
Lactic acid 0.10
Sodium lactate  0.10
Butylene glycol 12.00
Methylparaben 0.15
Dimethylpolysiloxane 0.40
Glyceryl stearate 0.40
Cetostearyl alcohol 0.35
Behenyl alcohol 0.35
Squalane 9.00
Hydrogenated phospholipids 0.20
Xanthan gum 0.10
Ethanol 5.00
Water (aqua) qs to 100.00

Formula 8. Antiperspirant stick12

Glycol distearate (Cutina AGS, Cognis) 2.40% w/w
Palmitic acid (and) stearic acid (Cutina FS45, Cognis) 2.75
Ceteareth-20 (Eumulgin B2, Cognis) 0.75
Ceteareth-30 (Eumulgin B3, Cognis) 0.75
Diisopropyl adipate (Ceraphyl 230, ISP) 6.00
Cocoglycerides (Novata AB, Cognis) 4.00
Cetyl palmitate (Cutina CP, Cognis) 5.00
Hydrogenated castor oil (Cutina HR, Cognis) 3.50
Cetearyl Behenate (Kesterwax K62, Koster Keunen) 4.50
Aluminum hydroxychloride, 50% in water 40.00
Talc 10.00
Tris (tetramethylhydroxypiperidenol) citrate (Tinogard Q, Ciba) 0.05
Propylene glycol 10.00
Water (aqua) qs to 100.00

Formula 10. Stable o/w sunscreen emulsion15

Cetearyl alcohol 1.00%w/w
Sodium cetearyl sulfate 0.20
Glyceryl stearate SE 0.20
Stearyl alcohol 1.00
Xanthan gum 0.10
Butylene glycol dicaprylate/dicaprate 5.00
C12-15 alkyl benzoate 5.00
Cyclomethicone 2.00
Glycerin 2.00
C12-38 acid triglyceride 1.00
2-propyl heptyl octanoate 3.00
Butyl methoxydibenzoylmethane 4.00
Phenylbenzimidazole sulfonic acid 2.00
Bis-ethylhexyloxyphenol methoxyphenyl triazine 2.00
Titanium dioxide 2.00
PVP-hexadecene copolymer 0.50
Starch 1.00
Vitamin E acetate 0.10
Disodium EDTA 0.10
Fragrance (parfum) 0.20
Preservative 0.30
Sodium hydroxide qs
Water (aqua) qs to 100.00

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