Patent Picks—Açai Palm Anti-aging, Sea Fennel and Tomato Healing, Ginger Antioxidant and More

By: Rachel L. Grabenhofer

Posted: November 27, 2012

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Compositions comprising natural anti-inflammatories
US Pat 8318217
Publication date: Nov. 27, 2012
Assignee: Johnson & Johnson Consumer Companies Inc.

This patent relates to a composition comprising an NFκB-inhibitor and an anti-inflammatory compound wherein the anti-inflammatory compound is not an NFκB-inhibitor and has an IC50 of about 70 μg/mL or less. It has been discovered that combinations of an NFκB-inhibitor with an anti-inflammatory compound having a low IC50 reduce the release of both inflammatory cytokines IL-1 and IL-8 from skin and other tissues, as well generally provide desirable NFκB-inhibition in skin and other tissues. The NFκB-inhibitor and anti-inflammatory compound are presented in a weight ratio from about 1:10 to about 10:1.

The disclosed composition includes an NFκB-inhibitor selected from the group consisting of substituted resorcinols, (E)-3-(4-methylphenylsulfonyl)-2-propenenitrile, extracts of Paulownia tomentosa wood, and combinations thereof.  The anti-inflammatory compound is selected from a wide range of options; such as Phellodendron amurense cortex extract (PCE), Tanacetum parthenium (feverfew), Ginkgo biloba, Lycium barbarum (gogi berry), Silybum marianum (milk thistle extract), Punica granatum (pomegranate), Lilium candidum (white lily) flower extract, Olea europaea, apple extract and others, and combinations thereof, wherein the substituted resorcinol is free of phenyl moieties.

Tomato-based topical formulation for enhanced healing of burns and UV and radiation erythema
US Pat 8318215
Publication date: Nov. 27, 2012
Assignee: Miriam Ryngler-Lewensztain

This invention describes a topical cream, ointment, spray or other topically administered composition used to enhance the healing of burns and UV and radiation erythema. The treatment reduces pain and inflammation, prevents blistering and maintains flexibility of the skin, as well as accelerates the normal healing process. The concentrated preparation consists of: a water-soluble powder obtained by concentration of mashed or crushed tomatoes under vacuum, followed by a drying process; at least one carotenoid that contains 6-20% lycopene; at least one phenolic acid that contains 0.1-5% caffeic acid; at least one antioxidant that contains 0.1-5% alpha-tocopherol or mixed tocopherols; at least one anti-inflammatory botanical that contains 0.1-1% alcoholic tincture of Calendula extract; and at least one antibacterial that contains 0.1-2.5% tea tree oil.