Patent Picks—Bioactive Ginger, Coumarin, Heat Shock Proteins and More for Wellness Cosmetics

Apr 16, 2013 | Contact Author | By: Rachel L. Grabenhofer, Cosmetics & Toiletries
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Title: Patent Picks—Bioactive Ginger, Coumarin, Heat Shock Proteins and More for Wellness Cosmetics
wellnessx skinx hairx coumarinx ginferx HSPx melaninx hair growthx
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Keywords: wellness | skin | hair | coumarin | ginfer | HSP | melanin | hair growth

Abstract: Patent Picks are taken from publicly available sources in the cosmetics, personal care and peripheral markets. This edition features technologies related to wellness cosmetics, including ginger anti-inflammation, cyclic skin whitening, coumarin hair growth, an anti-cellulite beta-2 adrenergic receptor agonist, Heat Shock Protein inhibition and more.

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R Grabenhofer, Patent Picks—Bioactive ginger, coumarin, heat shock proteins and more for wellness cosmetics, Cosm & Toile online, available at www.cosmeticsandtoiletries.com/research/patents/Patent-Picksmdashfor-Wellness-Cosmetics-203279021.html (Accessed Apr 16, 2013)

Patent Picks are taken from publicly available sources in the cosmetics, personal care and peripheral markets. This edition features technologies related to wellness cosmetics, including ginger anti-inflammation, cyclic skin whitening, coumarin hair growth, an anti-cellulite beta-2 adrenergic receptor agonist, Heat Shock Protein inhibition and more.

Absorbent article for maintaining or improving skin health
US Patent 8420883
Publication date: April 16, 2013
Assignee: The Procter & Gamble Company

This patent describes a method for maintaining and/or improving skin health by an absorbent article worn on the area of treatment. The article includes a vapor permeable backsheet, a liquid pervious topsheet positioned facing the backsheet, and an absorbent core located between the backsheet and the topsheet. The absorbent article includes skin care compositions that provide either a protective, nonocclusive function to avoid skin hyperhydration and exposure to materials exuded by the body, or agents that deliver, either directly or indirectly, skin care benefits. The composition may be in a variety of forms, including but not limited to emulsions, lotions, creams, ointments, salves, powders, suspensions, encapsulations, gels and the like.

Cyclic compound derivatives to inhibit melanin, hyper-pigmentation
US Patent 8420853
Publication date: April 16, 2013
Assignees: Wonkisopharm Co., Ltd; Y. Choi and J. Yhei

Disclosed in this invention are cyclic derivatives with potent, non-irritating, inhibitory effects on melanin formation and skin hyper-pigmentation activity. They can be used as therapeutics for treating and preventing skin diseases caused by the over-reproduced melanin. Cyclic compounds described include: 1-2-bis-octyloxy-cyclohexane, heptanoic acid 2-heptanoyloxy-trans-cyclohexyl ester, 2-ethyl-hexanoic acid 2-(2-ethyl-hexanoyloxy)-trans-cyclopentyl ester, octanoic acid 3-octanoyloxy-pyridine-2-yl ester, methyl-α-D-glucose tetra-O-butanoate, and 1,2-bis-hexyloxy-cyclohexane, or a pharmacologically acceptable salt thereof, among several others. They may be incorporated into skin lotions, astringents, massage creams, foundations, cleansing foams and various other beauty solutions.

Coumarin NFAT signal inhibitor, hair-growing agent
US Patent 8420836
Publication date: April 16, 2013
Assignee: Kao Corp.

These inventors describe pharmaceutical products, preparations for external use, cosmetic products and the like that have an NFAT signal inhibitory action, or a hair-growing action. The NFAT signal inhibitor described contains, as an active ingredient, at least one coumarin derivative.

Tripeptides and derivatives to improve skin structure
US Patent 8420778
Publication date: April 16, 2013
Assignee: DSM IP Assets B.V.

Disclosed in this patent are cosmetically active tripeptides, their derivatives and anti-aging compositions that diffuse rapidly, in sufficient concentration through the cell membrane up to the intracellular site of action, and strongly to stimulate collagen synthesis. This results from the capacity of the compounds to stimulating the growth factor TGFβ1, which is responsible for the anabolism of macromolecules in the skin matrix. The compounds therefore decisively influences the mechanical and physiological appearance of skin.

Inhibiting Hsp90 protein-protein interactions
US Patent 8420777
Publication date: April 16, 2013
Assignee: University of Massachusetts

The personal care industry has recently taken interest in Heat Shock Proteins (HSP), which, once induced by any method, protect cells against numerous stressors including UV radiation, increased metabolism, inflammation and others. In relation, this patent describes compounds that inhibit Heat Shock Protein 90 (Hsp90) interactions with Inhibitor of Apoptosis (IAP) proteins, such as Survivin, XIAP, cIAP1 or cIAP2, and methods for identifying and using such compounds. Specific regions, e.g., binding domains or motifs, mediate protein-protein interactions with Hsp90 and have been identified and characterized as mediating the anti-apoptotic effects of these IAP proteins. Peptides, peptide derivatives, peptidomimetics and small molecules that inhibit protein-protein interactions between Hsp90 and IAP proteins have been reported useful, for example, in the treatment of conditions associated with unwanted cellular proliferation.

N-phenylacetamide derivatives in compositions for skin, hair hygiene
US Patent 8420682
Publication date: April 16, 2013
Assignee: Galderma Research & Development

Disclosed in this patent are compositions for body and hair hygiene, particularly for combating or preventing greasy skin or hair, or a greasy scalp. Novel N-phenylacetamide derivatives are inhibitors of the enzyme SOAT-1 (Sterol-O-Acyl Transferase-1, also known as ACAT-1: Acyl-coenzyme A Cholesterol Acyl Transferase). The invention relates to the use of these derivatives in pharmaceutical or cosmetic compositions in the form of a cream, milk, lotion, gel, ointment, pomade, suspension of microspheres or nanospheres or lipid or polymer vesicles, shampoos and more.

Lipolytic methods for anti-cellulite effects
US Patent 8420625
Publication date: April 16, 2013
Assignee: Lithera, Inc.

Compositions, formulations, methods and systems for treating regional fat deposits are described herein that involve contacting a fat deposit with a composition comprising a long-acting beta-2 adrenergic receptor agonist and a compound that reduces desensitization of the target tissue to the long-acting agonist; for example, glucocorticosteroids and/or ketotifen. Embodiments of the composition are administered by injection and/or transdermally. It is believed that some embodiments of sustained modulation of adrenergic receptors in adipose tissue result in some combination of sustained lipolysis, reduced lipid content of the adipocyte, reduced adipocyte cell size, reduced adipose tissue mass or fat accumulation, and/or improved cosmetic appearance.

Bioactive ginger for cosmetic applications
US Patent 8420137
Publication date: April 16, 2013
Assignee: Evonik Goldschmidt GmbH

According to this patent, Curcuma longa (curcuma, turmeric) is a plant of the ginger family (Zigimberaceae), the roots and rhizome of which are used as dye and spice on account of its intense yellow color and characteristic taste. A variety of its biological effects have been described, including stimulation of gastric juice production, anti-cancer, anti-oxidative and anti-inflammatory effects. On account of the described bioactive effects, curcuminoid-containing extracts are interesting candidates for active ingredients for topical applications; however, the intense yellow/orange color prevents its use. Even in concentrations of 0.1% by mass, it causes a significant, unacceptable coloring of creams or lotions.

Therefore, this invention relates to a process for the preparation a Curcuma extract in such a manner as to improve its utility. The process is characterized by: A) liquid extraction of Curcuma rhizomes; B) optionally, separation of a curcuminoid-containing solid obtained by precipitation from the extraction mixture obtained in process step A); C) removal of solvents present from the extraction mixture; and D) distillation of the concentrate at a pressure of less than 1 bar to give the extract as distillate.