Patent Picks—Ceramide, Magnolia, Coumarin, Banyan Tree/Lotus/Clover Alternatives to Hydroquinone and More

By: Rachel L. Grabenhofer

Posted: September 18, 2012

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Oligonucleotide for modulating an isoform C beta-1 protein-kinase in the form of a skin depigmentation agent
US Patent 8252753
Publication date: Aug. 28, 2012
Assignee: LVMH Recherche

The purpose of this invention is an oligonucleotide with between 7 and 25 nucleotides, preferably 20, that is capable of specifically hybridizing with genes or products of genes coding for protein kinase C beta-1 (PKC beta-1). This invention also relates to the use of these oligonucleotide sequences as a depigmenting or bleaching agent for the skin in a cosmetic composition or in a topical pharmaceutical composition. According to the inventors, this invention solves the problems encountered in prior work by modulating the activation of the enzyme by phosphorylation instead of directly inhibiting the enzyme after it has been activated to obtain the depigmenting effect. Furthermore, these oligonucleotides according to the invention are not cytotoxic.

Composition comprising banyan tree, lotus and clover serum fractions to reduce hyperpigmentation
WIPO Patent Application WO/2012/115949
Publication date: Aug. 30,2012
Assignee: Akzo Nobel Chemicals International, B.V.; M. Koganov; and O. Dueva-Koganov

Disclosed herein is an invention relating to compositions comprising banyan tree, lotus and clover serum fractions and a method of improving the appearance of hyperpigmented spots. This method may comprise applying a composition incorporating the banyan tree, lotus and clover serum fractions to a hyperpigmented spot for a period of time sufficient to improve the appearance of the hyperpigmentation spot.